Evidence map›Paper›PMID 27812921›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2017

Electrical Impedance Myography and Its Applications in Neuromuscular Disorders.

Benjamin Sanchez, Seward B Rutkove

Registry-linked trialAbstract readReview
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07502989 (Convenient Quantification of Myopathic Change in Muscle Via Electrical Impedance Myography), which is not on this map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07502989 recruitingnot on this mapstarted 2025, after this paper: background citation

Convenient Quantification of Myopathic Change in Muscle Via Electrical Impedance Myography

Typeobservational_patient_registrySponsorBeth Israel Deaconess Medical CenterRan2025 to 2027Enrolled150ConditionsMyopathy, Muscular Dystrophies, Myositis, Myofibrillar MyopathyArmsElectrical Impedance Myography
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Reliability of bioimpedance spectroscopy in the upper trapezius muscle.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2026
    Article
  7. Junctions in Jeopardy: the neuromuscular junction is a selective pathological target in Charcot-Marie-Tooth disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
  8. Review
  9. Article
  10. "Muscle quality": rethinking an imprecise term.European geriatric medicine · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benjamin SanchezDepartment of Neurology, Division of Neuromuscular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA.
Seward B RutkoveDepartment of Neurology, Division of Neuromuscular Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. srutkove@bidmc.harvard.edu.

Funding

Electrical Impedance Myography in an Animal ModelR01NS055099 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2007 to 2022
$5.1M
Innovative Ultrasound Technology in Neuromuscular DiseaseK24NS060951 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI RUTKOVE, SEWARD B. · 2008 to 2017
$1.5M
NINDS NIH HHS K24 NS060951NINDS NIH HHS R01 NS055099
6 · The paper itself

Abstract

Electrical impedance myography (EIM) refers to the specific application of electrical bioimpedance techniques for the assessment of neuromuscular disorders. In EIM, a weak, high-frequency electrical current is applied to a muscle or muscle group of interest and the resulting voltages measured. Among its advantages, the technique can be used noninvasively across a variety of disorders and requires limited subject cooperation and evaluator training to obtain accurate and repeatable data. Studies in both animals and human subjects support its potential utility as a primary diagnostic tool, as well as a biomarker for clinical trial or individual patient use. This review begins by providing an overview of the current state and technological advances in electrical impedance myography and its specific application to the study of muscle. We then provide a summary of the clinical and preclinical applications of EIM for neuromuscular conditions, and conclude with an evaluation of ongoing research efforts and future developments.

Indexed as

ElectromyographyAnimalsElectric ImpedanceHumansMiceMuscle, SkeletalNeuromuscular DiseasesRatsdisuseElectrical impedanceinjurymusclemyopathyneurogenic disease

Identifiers

PMID27812921
PMCPMC5233633

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.