Evidence map›Paper›PMID 27812874›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2017

Detection of the Ubiquitinome in Cells Undergoing Oncogene-Induced Senescence.

Hengrui Zhu, Linh Le, Hsin-Yao Tang, David W Speicher, Rugang Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hengrui ZhuGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Linh LeGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, 19104, USA.
Hsin-Yao TangMolecular and Cellular Oncology Program and Proteomics Core, The Wistar Institute, Philadelphia, PA, 19104, USA.
David W SpeicherMolecular and Cellular Oncology Program and Proteomics Core, The Wistar Institute, Philadelphia, PA, 19104, USA.
Rugang ZhangGene Expression and Regulation Program, The Wistar Institute, Room 312, 3601 Spruce Street, Philadelphia, PA, 19104, USA. rzhang@wistar.org.
The Wistar Institute · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
TRAINING PROGRAM IN CELL AND MOLECULAR BIOLOGYT32GM007229 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1985 to 2023
$14.0M
Identification of Ovarian Cancer Plasma BiomarkersR01CA131582 · NCI · WISTAR INSTITUTE · PI SPEICHER, DAVID W. · 2009 to 2018
$4.1M
Role of BRCA1 Pathway in Regulating Oncogene-Induced SenescenceR01CA160331 · NCI · WISTAR INSTITUTE · PI ZHANG, RUGANG · 2012 to 2021
$4.0M
NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA131582NCI NIH HHS R01 CA160331NIGMS NIH HHS T32 GM007229
6 · The paper itself

Abstract

Senescent cells exhibit dramatic changes in protein post-translational modifications. Here, we describe a method, stable isotope labeling with amino acids in cell culture (SILAC) coupled to liquid chromatography tandem mass spectrometry (LC-MS/MS), to identify changes in the ubiquitinome in cells that have undergone oncogene-induced senescence.

Indexed as

Cellular SenescenceProteomeProteomicsCell LineChromatography, AffinityChromatography, LiquidFibroblastsGenes, rasHumansIsotope LabelingOncogenesProtein Processing, Post-TranslationalTandem Mass SpectrometryUbiquitinsProteomeUbiquitinsLiquid chromatography tandem mass spectrometry (LC-MS/MS)Post-translational modificationSenescenceStable isotope labeling with amino acids in cell culture (SILAC)UbiquitinUbiquitinomeUbiquitin-proteosome pathway

Identifiers

PMID27812874
PMCPMC5572468
OpenAlexW2548032599

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.