ArticleJournal of applied oral science : revista FOB
The effect of hippophae rhamnoides extract on oral mucositis induced in rats with methotrexate.
Article in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- The effect of Hippophae rhamnoides on Hydroxychloroquine-Induced stomatitis in rats.BMC complementary medicine and therapies · 2025Article
- The role of sea buckthorn in skin and mucosal health: a review from an anti-inflammatory perspective.Frontiers in pharmacology · 2025Review
- Examining hepatoprotective effects of astaxanthin against methotrexate-induced hepatotoxicity in rats through modulation of Nrf2/HO-1 pathway genes.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Natural Products for the Prevention and Treatment of Oral Mucositis-A Review.International journal of molecular sciences · 2022Review
- Evaluation of the antiapoptotic and anti-inflammatory properties of chitosan in methotrexate-induced oral mucositis in rats.Molecular biology reports · 2022Article
- Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation.Journal of applied oral science : revista FOB · 2022Article
- Emerging approaches of wound healing in experimental models of high-grade oral mucositis induced by anticancer therapy.Oncotarget · 2021Article
- Article
- Beneficial Biological Activities ofBiomedicines · 2020Review
- Effect of irinotecan on the tongue mucosa of juvenile male albino rat at adulthood.International journal of experimental pathology · 2019Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective: To investigate the effect of HRE (Hippophae rhamnoides extract) on oral mucositis induced in rats with MTX. MATERIAL AND
methods: Experimental animals were divided into groups as healthy (HG), HRE+MTX (HMTX), and control group, which received MTX (MTXC). HMTX group received 50 mg/kg HRE while MTXC and HG groups received equivolume distilled water with gavage once a day. After one hour of HRE and distilled water administration, HMTX and MTXC groups received a single dose of oral MTX 5 mg/ kg. This procedure was repeated for one month.
results: The levels of MDA, IL-1β, and TNF-α were found to be significantly higher in the cheek, lower lip, and tongue tissue of the animals receiving MTX, compared with HG and HMTX groups; however, these parameters were lower in the cheek and low lip tissue, and a milder damage ocurred in these tissues, compared with the tongue tissue in MTXC group. No histopathologic damage was observed in the cheek, lower lip, and tongue tissues of the rats treated with HRE.
conclusion: This findings indicate that HRE as a natural product is an important advantage compared with synthetic drugs for prophylaxis of oral mucositis developed due to MTX.
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