ArticleJCI insight2016
Muscle oxidative phosphorylation quantitation using creatine chemical exchange saturation transfer (CrCEST) MRI in mitochondrial disorders.
Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Phase 2a Study of NAD+ Precursor Supplementation in Friedreich's Ataxia
Natural History Study of Mitochondrial Myopathy
The Utility of pGz in Primary Mitochondrial Disorders
Who cites it
32 citing papers in PubMed.
- Double blind trial of a deuterated form of linoleic acid (RT001) in Friedreich ataxia.Journal of neurology · 2023Trial
- Trial
- Neuropathology of Friedreich ataxia and its links to metabolic pathways.Neurodegenerative disease management · 2026Review
- A Novel CEST-Based Approach for Reliably Assessing Skeletal Muscle Oxidative Phosphorylation: OXCEST.Magnetic resonance in medicine · 2026Article
- Reliability of In Vivo Creatine-Weighted Chemical Exchange Saturation Transfer (CrCEST) MRI in Calf Skeletal Muscle of Healthy Volunteers at 3 T.Journal of magnetic resonance imaging : JMRI · 2025Article
- Personalized and muscle-specific OXPHOS measurement with integrated CrCEST MRI and proton MR spectroscopy.Nature communications · 2024Article
- Quantitative Assessment of Peripheral Oxidative Metabolism With a New DynamicJournal of magnetic resonance imaging : JMRI · 2024Article
- Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases.Epigenomics · 2024Review
- A systematic review of the relationship between muscle oxygen dynamics and energy rich phosphates. Can NIRS help?BMC sports science, medicine & rehabilitation · 2024Article
- Biogenic Imaging Contrast Agents.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Design and rationale of re-energize fontan: Randomized exercise intervention designed to maximize fitness in fontan patients.American heart journal · 2023Article
- In vivo pH mapping with omega plot-based quantitative chemical exchange saturation transfer MRI.Magnetic resonance in medicine · 2023Article
- Article
- In vivo assessment of OXPHOS capacity using 3 T CrCEST MRI in Friedreich's ataxia.Journal of neurology · 2022Article
- A Multimodal MR Imaging Study of the Effect of Hippocampal Damage on Affective and Cognitive Functions in a Rat Model of Chronic Exposure to a Plateau Environment.Neurochemical research · 2022Article
- Development of a Mitochondrial Myopathy-Composite Assessment Tool.JCSM clinical reports · 2021Article
- Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism.ESC heart failure · 2021Article
- Mitochondrial and metabolic dysfunction in Friedreich ataxia: update on pathophysiological relevance and clinical interventions.Neuronal signaling · 2021Review
- Recovery kinetics of creatine in mild plantar flexion exercise using 3D creatine CEST imaging at 7 Tesla.Magnetic resonance in medicine · 2021Article
- The Role of Serum Levels of Neurofilament Light (NfL) Chain as a Biomarker in Friedreich Ataxia.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
22 authors.
Funding
Abstract
Systemic mitochondrial energy deficiency is implicated in the pathophysiology of many age-related human diseases. Currently available tools to estimate mitochondrial oxidative phosphorylation (OXPHOS) capacity in skeletal muscle in vivo lack high anatomic resolution. Muscle groups vary with respect to their contractile and metabolic properties. Therefore, muscle group-specific estimates of OXPHOS would be advantageous. To address this need, a noninvasive creatine chemical exchange saturation transfer (CrCEST) MRI technique has recently been developed, which provides a measure of free creatine. After exercise, skeletal muscle can be imaged with CrCEST in order to make muscle group-specific measurements of OXPHOS capacity, reflected in the recovery rate (τCr) of free Cr. In this study, we found that individuals with genetic mitochondrial diseases had significantly (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.