Evidence map›Paper›PMID 27812535›Full record

ArticleNPJ Parkinson's disease2016

Blood biomarker for Parkinson disease: peptoids.

Umar Yazdani, Sayed Zaman, Linda S Hynan, L Steven Brown, Richard B Dewey, David Karp, Dwight C German

Open access · goldAbstract read
In one paragraph

Article in NPJ Parkinson's disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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  6. The Potential ofGenes · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Umar YazdaniDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sayed ZamanDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Linda S HynanDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA; Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.
L Steven BrownDepartment of Neurology & Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Richard B DeweyDepartment of Neurology & Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
David KarpDepartment of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dwight C GermanDepartment of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA.
The University of Texas Southwestern Medical Center · US

Funding

Diagnostic and prognostic biomarkers for Parkinsons diseaseU01NS082148 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI DEWEY, RICHARD B, GERMAN, DWIGHT C. · 2012 to 2016
$3.0M
NINDS NIH HHS U01 NS082148
6 · The paper itself

Abstract

Parkinson disease (PD) is the second most common neurodegenerative disease. Because dopaminergic neuronal loss begins years before motor symptoms appear, a biomarker for the early identification of the disease is critical for the study of putative neuroprotective therapies. Brain imaging of the nigrostriatal dopamine system has been used as a biomarker for early disease along with cerebrospinal fluid analysis of α-synuclein, but a less costly and relatively non-invasive biomarker would be optimal. We sought to identify an antibody biomarker in the blood of PD patients using a combinatorial peptoid library approach. We examined serum samples from 75 PD patients, 25

Identifiers

PMID27812535
PMCPMC5088434
OpenAlexW2468489786

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.