Evidence map›Paper›PMID 27812531›Full record

ArticleBioMed research international2016

Cell Electrical Impedance as a Novel Approach for Studies on Senescence Not Based on Biomarkers.

Jung-Joon Cha, Yangkyu Park, Joho Yun, Hyeon Woo Kim, Chang-Ju Park, Giseok Kang, Minhyun Jung, Boryeong Pak, Suk-Won Jin, Jong-Hyun Lee

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Jung-Joon ChaDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Yangkyu ParkSchool of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Joho YunDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Hyeon Woo KimDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Chang-Ju ParkDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Giseok KangDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Minhyun JungSchool of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Boryeong PakSchool of Life Sciences, Gwangju Institute of Science and Technology (GIST), Laboratory of Vascular Development No. 115, Life Science Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.
Suk-Won JinSchool of Life Sciences, Gwangju Institute of Science and Technology (GIST), Laboratory of Vascular Development No. 115, Life Science Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea; Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University, 300 George Street, New Haven, CT, USA.
Jong-Hyun LeeDepartment of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea; School of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST), MEMS and Nano Systems Laboratory No. 317, Dasan Building, 123 Cheomdangwagi-ro, Buk-gu, Gwangju 61005, Republic of Korea.ORCID 0000-0001-6546-973X
Gwangju Institute of Science and Technology · KRYale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Senescence of cardiac myocytes is frequently associated with heart diseases. To analyze senescence in cardiac myocytes, a number of biomarkers have been isolated. However, due to the complex nature of senescence, multiple markers are required for a single assay to accurately depict complex physiological changes associated with senescence. In single cells, changes in both cytoplasm and cell membrane during senescence can affect the changes in electrical impedance. Based on this phenomenon, we developed MEDoS, a novel microelectrochemical impedance spectroscopy for diagnosis of senescence, which allows us to precisely measure quantitative changes in electrical properties of aging cells. Using cardiac myocytes isolated from 3-, 6-, and 18-month-old isogenic zebrafish, we examined the efficacy of MEDoS and showed that MEDoS can identify discernible changes in electrical impedance. Taken together, our data demonstrated that electrical impedance in cells at different ages is distinct with quantitative values; these results were comparable with previously reported ones. Therefore, we propose that MEDoS be used as a new biomarker-independent methodology to obtain quantitative data on the biological senescence status of individual cells.

Indexed as

AnimalsBiomarkersCell MembraneCellular SenescenceCytoplasmDielectric SpectroscopyElectric ImpedanceMicroelectrodesMyocytes, CardiacZebrafishBiomarkers

Identifiers

PMID27812531
PMCPMC5080468
OpenAlexW2530279996

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.