ArticleSpringerPlus2016
Relationship between AZFc deletions and testicular histology in infertile South Chinese men with azoospermia and severe oligospermia.
Article in SpringerPlus, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Association of Y chromosome AZF region microdeletions with recurrent miscarriage in Iranian couples: A case-control study.Molecular genetics & genomic medicine · 2024Article
- Gene Polymorphism, Microdeletion, and Gene Expression ofReports of biochemistry & molecular biology · 2023Article
- The predictive factors of successful sperm retrieval for men with Y chromosome AZFc microdeletion.Journal of assisted reproduction and genetics · 2022Article
- Histology and sperm retrieval among men with Y chromosome microdeletions.Translational andrology and urology · 2021Review
- Partial-AZFc deletions in Chilean men with primary spermatogenic impairment: gene dosage and Y-chromosome haplogroups.Journal of assisted reproduction and genetics · 2020Article
- Genetic disorders and male infertility.Reproductive medicine and biology · 2020Review
- Deletion of b1/b3 shows risk for expanse of Yq microdeletion in male offspring: Case report of novel Y chromosome variations.Medicine · 2020Article
- An infertile patient with Y chromosome b1/b3 deletion presenting with congenital bilateral absence of the vas deferens with normal spermatogenesis.Clinical and experimental reproductive medicine · 2018Article
- Progress and future prospect ofOncotarget · 2017Review
- Screening of the Combined Risk of Genetics and Epidemiology on Infertility Among Indian Men: Synergistic Effect of AZFc Partial Deletions and Habits of Smokeless Chewing Tobacco.American journal of men's healthArticle
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe AZFc deletion has been associated with wide range of phenotypes including complete absence of germ cells in the testes (SCOS), reduction in germ cells hypospermatogenesis, and maturation arrest. The main objective of this study was to evaluate the relationship between AZFc microdeletions and testicular histology in South Chinese men with azoospermia or severe oligospermia.
findings338 men presenting with idiopathic non-obstructive azoospermia or severe oligospermia were evaluated between March 2012 and April 2015. Thirty-nine of the patients examined had an AZFc deletion (10.9 %). Testicular cytopathology was examined in 25 patients with an AZFc microdeletion and 14 with an AZFc deletion. There was no significant difference in the testicular histology of patients with partial or complete AZFc deletions (Mann-Whitney U = 152.500, p = 0.515). There was an association between testicular histology and gr/gr, b1/b3 or b2/b3 deletion (Fisher's exact test, p = 0.013).
conclusionsMen with a gr/gr partial deletion were at higher risk of having hypospermatogenesis or maturation arrest. Men with a b1/b3 partial deletion were at higher risk of having maturation arrest. Men with a b2/b3 partial deletion were at higher risk of having maturation arrest or complete absence of germ cells in the testes.
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