Norepinephrine transporter expression is inversely associated with glycaemic indices: a pilot study in metabolically diverse persons with overweight and obesity.
N E Straznicky, L Guo, S J Corcoran, M D Esler, S E Phillips, C I Sari, M T Grima, S Karapanagiotidis, C Y Wong, N Eikelis and 5 more
Article in Obesity science & practice, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors at 3 institutions in 1 country.
N E StraznickyHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
L GuoHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
S J CorcoranHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
M D EslerHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
S E PhillipsHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
C I SariHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
M T GrimaHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
S KarapanagiotidisAlfred Baker Medical Unit Baker IDI Heart & Diabetes Institute Melbourne Australia.
C Y WongAlfred Baker Medical Unit Baker IDI Heart & Diabetes Institute Melbourne Australia; Cardiology, Western Health University of Melbourne Melbourne Australia.
N EikelisHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
J A MarianiHeart Failure Research Group Baker IDI Heart & Diabetes Institute Melbourne Australia; Faculty of Medicine, Nursing and Health Sciences Monash University Melbourne Australia.
D KobayashiHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia.
J B DixonHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia; Primary Health Care Monash University Melbourne Australia.
G W LambertHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia; Faculty of Medicine, Nursing and Health Sciences Monash University Melbourne Australia.
E A LambertHuman Neurotransmitters Laboratory Baker IDI Heart & Diabetes Institute Melbourne Australia; Departments of Physiology Monash University Melbourne Australia; Departments of Physiology University of Melbourne Melbourne Australia.
Baker Heart and Diabetes Institute · AUUniversity of Melbourne · AUMonash University · AU
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
objectiveThe objective of this study was to examine the cross-sectional relationship between the expression of norepinephrine transporter (NET), the protein responsible for neuronal uptake-1, and indices of glycaemia and hyperinsulinaemia, in overweight and obese individuals.
methodsThirteen non-medicated, non-smoking subjects, aged 58 ± 1 years (mean ± standard error of the mean), body mass index (BMI) 31.4 ± 1.0 kg m
resultsNorepinephrine transporter expression was inversely associated with fasting plasma glucose (
conclusionsHyperglycaemia is associated with reduced peripheral NET expression. Further studies are required to identify the direction of causality.
Indexed as
Hyperglycaemianorepinephrine transporterobesitysympathetic nervous system
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Norepinephrine transporter expression is inversely associated with glycaemic indices: a pilot study in metabolically diverse persons with overweight and obesity. · full record | OpenQuestion