ArticleFrontiers in behavioral neuroscience2016
Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 85 citations in OpenAlex.
- Groups of familiar male rats form unstable partner preferences when play fighting during the juvenile period.iScience · 2025Article
- Exploring rodent prosociality: A conceptual framework.Translational neuroscience · 2025Review
- Juvenile male rats form preferences based on strain when playing in groups but not in pairs.Frontiers in behavioral neuroscience · 2025Article
- Isolated during adolescence: long-term impact on social behavior, pain sensitivity, and the oxytocin system in male and female rats.Biology of sex differences · 2024Article
- Psychotomimetic compensation versus sensitization.Pharmacology research & perspectives · 2024Review
- Disentangling developmental effects of play aspects in rat rough-and-tumble play.Biology letters · 2024Article
- Synaptic pruning during adolescence shapes adult social behavior in both males and females.Developmental psychobiology · 2024Article
- Effects of reduced kinematic and social play experience on affective appraisal of human-rat play in rats.Frontiers in zoology · 2023Article
- Resilience to substance use disorder following childhood maltreatment: association with peripheral biomarkers of endocannabinoid function and neural indices of emotion regulation.Molecular psychiatry · 2023Article
- Comparing the ontogeny, neurobiology, and function of social play in hamsters and rats.Neuroscience and biobehavioral reviews · 2023Review
- Liposaccharide-induced sustained mild inflammation fragments social behavior and alters basolateral amygdala activity.Psychopharmacology · 2023Article
- Extraction and Simultaneous Quantification of Endocannabinoids and Endocannabinoid-Like Lipids in Biological Tissues.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Wildtype peers rescue social play and 50-kHz ultrasonic vocalization deficits in juvenile femaleFrontiers in behavioral neuroscience · 2023Article
- Social Play Behavior Is Critical for the Development of Prefrontal Inhibitory Synapses and Cognitive Flexibility in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Dopamine Transporter Knockout Rats Show Impaired Wellbeing in a Multimodal Severity Assessment Approach.Frontiers in behavioral neuroscience · 2022Article
- Developmental differences in amygdala projection neuron activation associated with isolation-driven changes in social preference.Frontiers in behavioral neuroscience · 2022Article
- The Influence of Social Isolation on Social Orientation, Sociability, Social Novelty Preference, and Hippocampal Parvalbumin-Expressing Interneurons in Peripubertal Rats - Understanding the Importance of Meeting Social Needs in Adolescence.Frontiers in behavioral neuroscience · 2022Article
- The rough-and-tumble play of rats as a natural behavior suitable for studying the social brain.Frontiers in behavioral neuroscience · 2022Article
- Social play experience in juvenile rats is indispensable for appropriate socio-sexual behavior in adulthood in males but not females.Frontiers in behavioral neuroscience · 2022Article
- Synergistic consequences of early-life social isolation and chronic stress impact coping and neural mechanisms underlying male prairie vole susceptibility and resilience.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Social affiliation is essential for many species and gains significant importance during adolescence. Disturbances in social affiliation, in particular social rejection experiences during adolescence, affect an individual's well-being and are involved in the emergence of psychiatric disorders. The underlying mechanisms are still unknown, partly because of a lack of valid animal models. By using a novel animal model for social peer-rejection, which compromises adolescent rats in their ability to appropriately engage in playful activities, here we report on persistent impairments in social behavior and dysregulations in the endocannabinoid (eCB) system. From postnatal day (pd) 21 to pd 50 adolescent female Wistar rats were either reared with same-strain partners (control) or within a group of Fischer 344 rats (inadequate social rearing, ISR), previously shown to serve as inadequate play partners for the Wistar strain. Adult ISR animals showed pronounced deficits in social interaction, social memory, processing of socially transmitted information, and decreased pain sensitivity. Molecular analysis revealed increased CB1 receptor (CB1R) protein levels and CP55, 940 stimulated [
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.