ArticleResearch and reports in neonatology2015
Response to bronchodilators in very preterm infants with evolving bronchopulmonary dysplasia.
Article in Research and reports in neonatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Pulmonary function tests in the neonatal intensive care unit and beyond: a clinical review.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Predictors of Bronchodilator Response on Oscillometry and Spirometry in School-Age Children With Bronchopulmonary Dysplasia.Pediatric pulmonology · 2025Observational
- Current and Emerging Therapies for Prevention and Treatment of Bronchopulmonary Dysplasia in Preterm Infants.Paediatric drugs · 2025Review
- Comprehensive pulmonary function analysis identifies predominant obstructive phenotype in former premature infants around one year of age.Pediatric pulmonology · 2024Article
- Bronchodilator responsiveness and dysanapsis in bronchopulmonary dysplasia.ERJ open research · 2022Article
- Pharmacotherapy in Bronchopulmonary Dysplasia: What Is the Evidence?Frontiers in pediatrics · 2022Review
- Pulmonary Function Tests in Very Low Birth Weight Infants Screened for Pulmonary Hypertension: A Pilot Study.The Journal of pediatrics · 2021Observational
- Response to first dose of inhaled albuterol in mechanically ventilated preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- An Update on the Prevention and Management of Bronchopulmonary Dysplasia.Pediatric health, medicine and therapeutics · 2021Review
- Pharmacoepidemiology of Drug Exposure in Intubated and Non-Intubated Preterm Infants With Severe Bronchopulmonary Dysplasia.Frontiers in pharmacology · 2021Article
- Inhaled bronchodilator exposure in the management of bronchopulmonary dysplasia in hospitalized infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Pulmonary function in extremely low birth weight infants with bronchopulmonary dysplasia before hospital discharge.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Trajectories of Lung Function in Infants and Children: Setting a Course for Lifelong Lung Health.Pediatrics · 2020Review
- Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia.American journal of physiology. Lung cellular and molecular physiology · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere are few effective and safe medications to treat very low birth weight (VLBW) infants with evolving BPD. Bronchodilators are often given to patients who have clinical signs of reactive airway disease, but there is not enough information regarding their effectiveness within this population.
objectiveTo quantify the pulmonary function response to bronchodilator therapy in a population of VLBW infants with evolving BPD. DESIGN/
methodsThis is a retrospective analysis of an ongoing large database of pulmonary function tests (PFTs) in premature infants. We reviewed pre and post bronchodilator PFTs ordered by a physician due to concern for reactive airway disease. Inclusion criteria: BW< 1500 grams; > 14 days of age; admission diagnosis of respiratory distress syndrome; requiring ongoing oxygen, CPAP or ventilator support at the time of PFT. PFTs were done prior to albuterol therapy and repeated 30 minutes after the therapy was given. PFTs included the measurement of passive respiratory mechanics with the single breath occlusion technique, including passive respiratory compliance (Crs), resistance (Rrs) and tidal volume (Vt).
results40 VLBW infants (mean gestation of 27.4 weeks; mean birth weight (BW) of 848 grams) were identified as having PFTs. 29 of these patients had a BW of ≤ 1000 grams. Patients were studied at a mean corrected gestational age of 34.9 weeks. 29 of 40 were extubated at the time of the PFT. Of these patients, 21 (52.5%) had a decrease in Rrs of ≥10%. From the other 19 patients, 5 (12.5%) had a decrease of 0 to < 10% in Rrs, 14 (35%) showed no response to therapy. There was no significant difference in Crs between groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.