ArticlePLoS genetics2016
Experimental Evolution Reveals Interplay between Sch9 and Polyploid Stability in Yeast.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Asymmetric genome merging leads to gene expression novelty through nucleo-cytoplasmic disruptions and transcriptomic shock in Chlamydomonas triploids.The New phytologist · 2025Article
- European farmhouse brewing yeasts form a distinct genetic group.Applied microbiology and biotechnology · 2024Article
- Whole-genome duplication in the Multicellularity Long Term Evolution Experiment.bioRxiv : the preprint server for biology · 2024Article
- Rapid evolutionary repair by secondary perturbation of a primary disrupted transcriptional network.EMBO reports · 2023Article
- A novel narnavirus is widespread in Saccharomyces cerevisiae and impacts multiple host phenotypes.G3 (Bethesda, Md.) · 2023Article
- Sublinear scaling of the cellular proteome with ploidy.Nature communications · 2022Article
- Gradual evolution of allopolyploidy in Arabidopsis suecica.Nature ecology & evolution · 2021Article
- Review
- Polyploid engineering by increasing mutant gene dosage in yeasts.Microbial biotechnology · 2021Article
- Molecular signatures of aneuploidy-driven adaptive evolution.Nature communications · 2020Article
- Enhanced Wort Fermentation withApplied and environmental microbiology · 2018Article
- Spindle Dynamics Model Explains Chromosome Loss Rates in Yeast Polyploid Cells.Frontiers in genetics · 2018Article
- Overproduction of Sch9 leads to its aggregation and cell elongation in Saccharomyces cerevisiae.PloS one · 2018Article
- Meeting Report on Experimental Approaches to Evolution and Ecology Using Yeast and Other Model Systems.G3 (Bethesda, Md.) · 2017Article
- Ploidy Variation in Fungi: Polyploidy, Aneuploidy, and Genome Evolution.Microbiology spectrum · 2017Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyploidization has crucial impacts on the evolution of different eukaryotic lineages including fungi, plants and animals. Recent genome data suggest that, for many polyploidization events, all duplicated chromosomes are maintained and genome reorganizations occur much later during evolution. However, newly-formed polyploid genomes are intrinsically unstable and often quickly degenerate into aneuploidy or diploidy. The transition between these two states remains enigmatic. In this study, laboratory evolution experiments were conducted to investigate this phenomenon. We show that robust tetraploidy is achieved in evolved yeast cells by increasing the abundance of Sch9-a protein kinase activated by the TORC1 (Target of Rapamycin Complex 1) and other signaling pathways. Overexpressing SCH9, but not TOR1, allows newly-formed tetraploids to exhibit evolved phenotypes and knocking out SCH9 diminishes the evolved phenotypes. Furthermore, when cells were challenged with conditions causing ancestral cells to evolve aneuploidy, tetraploidy was maintained in the evolved lines. Our results reveal a determinant role for Sch9 during the early stage of polyploid evolution.
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