ArticlePloS one2016
Living at Higher Altitude and Incidence of Overweight/Obesity: Prospective Analysis of the SUN Cohort.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of metabolic syndrome and its components according to altitude levels: a systematic review and meta-analysis.Scientific reports · 2024Pooled it
- Disruption of sphingolipid metabolism triggers lung vascular inflammation and aging-like changes under hypoxia through VDAC1-mediated mitochondrial DNA release.Apoptosis : an international journal on programmed cell death · 2026Article
- Body mass index affects EEG microstate dynamics through blood viscosity in high-altitude environments.Frontiers in neuroscience · 2026Article
- HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity.Cell · 2025Article
- Association between air pollution, altitudes, and overweight/obesity in China.Frontiers in public health · 2025Article
- Organ-specific fuel rewiring in acute and chronic hypoxia redistributes glucose and fatty acid metabolism.Cell metabolism · 2023Article
- A novel clinical prediction scoring system of high-altitude pulmonary hypertension.Frontiers in cardiovascular medicine · 2023Article
- Review
- Clinical characteristics and mortality associated with COVID-19 at high altitude: a cohort of 5161 patients in Bogotá, Colombia.International journal of emergency medicine · 2022Article
- Hypoxic Exercise Exacerbates Hypoxemia and Acute Mountain Sickness in Obesity: A Case Analysis.International journal of environmental research and public health · 2021Article
- Association of altitude and urbanization with hypertension and obesity: analysis of the Nepal Demographic and Health Survey 2016.International health · 2021Article
- Distinct Nutrient Intake Style in Inhabitants of Ultra-High-Altitude Areas in North of Tibet, China: A Cross-Sectional Study Based on Newly Developed Tibetan Food Frequency Questionnaires.Frontiers in nutrition · 2021Article
- Stroke-Related Mortality at Different Altitudes: A 17-Year Nationwide Population-Based Analysis From Ecuador.Frontiers in physiology · 2021Article
- Erythropoietin regulates metabolic response in mice via receptor expression in adipose tissue, brain, and bone.Experimental hematology · 2020Review
- GDF15: A Hormone Conveying Somatic Distress to the Brain.Endocrine reviews · 2020Review
- Twelve Weeks of Aerobic Exercise at the Lactate Threshold Improves Autonomic Nervous System Function, Body Composition, and Aerobic Performance in Women with Obesity.Journal of obesity & metabolic syndrome · 2020Article
- Low Elevation and Physical Inactivity are Associated with a Higher Prevalence of Metabolic Syndrome in Ecuadorian Adults: A National Cross-Sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Oxygenation of adipose tissue: A human perspective.Acta physiologica (Oxford, England) · 2020Review
- Effects of Erythropoietin in White Adipose Tissue and Bone Microenvironment.Frontiers in cell and developmental biology · 2020Review
- Effects of exercise training at lactate threshold and detraining for 12 weeks on body composition, aerobic performance, and stress related variables in obese women.Journal of exercise nutrition & biochemistry · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundResidence at high altitude has been associated with lower obesity rates probably due to hypoxia conditions. However, there is no evidence of this association in a free-living population.
objectivesWe assessed the association between the altitude where each participant of a Spanish cohort (the SUN Project) was living and the incidence of overweight/obesity.
methodsThe SUN Project is a dynamic, prospective, multipurpose cohort of Spanish university graduates with a retention rate of 89%. We included in the analysis 9 365 participants free of overweight/obesity at baseline. At the baseline questionnaire, participants reported their postal code and the time they had been living in their city/village. We imputed the altitude of each postal code according to the data of the Spanish National Cartographic Institute and categorized participants in tertiles. We used Cox regression models to adjust for potential confounding variables.
resultsDuring a median follow-up of 10 years, we identified 2 156 incident cases of overweight/obesity. After adjusting for sex, age, time of residence at current city, baseline body mass index, physical activity, sedentarism and years of education (≤ 3 years, ≥ 4 years, Master/PhD), those participants in the third tertile (>456 m) exhibited a statistically significant 14% reduction in the risk of developing overweight/obesity in comparison to those in the first tertile (<124 m) (adjusted HR = 0.86; 95% CI: 0.77, 0.96).
conclusionsLiving in cities of higher altitude was inversely associated with the risk of developing overweight/obesity in a cohort of Spanish university graduates.
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