ArticleScientific reports2016
Constitutive cyclic GMP accumulation in Arabidopsis thaliana compromises systemic acquired resistance induced by an avirulent pathogen by modulating local signals.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Interplay of different signaling mechanisms in regulating programmed cell death during plant development and in response to stresses.Protoplasma · 2026Review
- Identification and validation of hub genes associated with biotic and abiotic stresses by modular gene co-expression analysis in Oryza sativa L.Scientific reports · 2025Article
- Cyclic guanosine monophosphate improves salt tolerance in Solanum lycopersicum.Journal of plant research · 2024Article
- A methane-cGMP module positively influences adventitious rooting.Plant cell reports · 2023Article
- Intertwined Roles of Reactive Oxygen Species and Salicylic Acid Signaling Are Crucial for the Plant Response to Biotic Stress.International journal of molecular sciences · 2022Review
- BdGUCD1 and Cyclic GMP Are Required for Responses ofInternational journal of molecular sciences · 2022Article
- Molecular Targets and Biological Functions of cAMP Signaling inBiomolecules · 2021Article
- Moonlighting Proteins Shine New Light on Molecular Signaling Niches.International journal of molecular sciences · 2021Review
- Computational Identification of Functional Centers in Complex Proteins: A Step-by-Step Guide With Examples.Frontiers in bioinformatics · 2021Article
- Downstream Targets of Cyclic Nucleotides in Plants.Frontiers in plant science · 2018Article
- Discovery of Novel Functional Centers With Rationally Designed Amino Acid Motifs.Computational and structural biotechnology journal · 2018Review
- Moonlighting Proteins and Their Role in the Control of Signaling Microenvironments, as Exemplified by cGMP and Phytosulfokine Receptor 1 (PSKR1).Frontiers in plant science · 2018Article
- Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling.Frontiers in plant science · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The infection of Arabidopsis thaliana plants with avirulent pathogens causes the accumulation of cGMP with a biphasic profile downstream of nitric oxide signalling. However, plant enzymes that modulate cGMP levels have yet to be identified, so we generated transgenic A. thaliana plants expressing the rat soluble guanylate cyclase (GC) to increase genetically the level of cGMP and to study the function of cGMP in plant defence responses. Once confirmed that cGMP levels were higher in the GC transgenic lines than in wild-type controls, the GC transgenic plants were then challenged with bacterial pathogens and their defence responses were characterized. Although local resistance was similar in the GC transgenic and wild-type lines, differences in the redox state suggested potential cross-talk between cGMP and the glutathione redox system. Furthermore, large-scale transcriptomic and proteomic analysis highlighted the significant modulation of both gene expression and protein abundance at the infection site, inhibiting the establishment of systemic acquired resistance. Our data indicate that cGMP plays a key role in local responses controlling the induction of systemic acquired resistance in plants challenged with avirulent pathogens.
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