Evidence map›Paper›PMID 27811963›Full record

ArticleScientific reports2016

A sequence variant associating with educational attainment also affects childhood cognition.

Bjarni Gunnarsson, Guðrún A Jónsdóttir, Gyða Björnsdóttir, Bettina Konte, Patrick Sulem, Snædís Kristmundsdóttir, Birte Kehr, Ómar Gústafsson, Hannes Helgason, Paul D Iordache and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Bjarni GunnarssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Guðrún A JónsdóttirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Gyða BjörnsdóttirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Bettina KonteDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Patrick SulemdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Snædís KristmundsdóttirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Birte KehrdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Ómar GústafssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Hannes HelgasondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Paul D IordachedeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Sigurgeir ÓlafssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Michael L FriggedeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Guðmar ÞorleifssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Sunna ArnarsdóttirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Berglind StefánsdóttirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Ina GieglingDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Srdjan DjurovicNORMENT, KG Jebsen Centre for Psychosis Research, Department of Clinical Science, University of Bergen, Bergen, Norway.
Kjetil S SundetDepartment of Psychology, University of Oslo, Oslo 0373, Norway.
Thomas EspesethDepartment of Psychology, University of Oslo, Oslo 0373, Norway.
Ingrid MelleDepartment of Medical Genetics, Oslo University Hospital, Oslo 0450, Norway.
Annette M HartmannDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Unnur ThorsteinsdottirdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Augustine KongdeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Daníel F GuðbjartssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Ulrich EttingerDepartment of Psychology, University of Bonn, Bonn, Germany.
Ole A AndreassenNORMENT - KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo N-0316, Norway.
Dan RujescuDepartment of Psychiatry, Psychotherapy and Psychosomatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany.
Jónas G HalldórssonFaculty of Medicine, University of Iceland, Reykjavik, Iceland.
Hreinn StefánssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Bjarni V HalldórssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Kári StefánssondeCODE Genetics/Amgen, Inc., Reykjavik, Iceland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Only a few common variants in the sequence of the genome have been shown to impact cognitive traits. Here we demonstrate that polygenic scores of educational attainment predict specific aspects of childhood cognition, as measured with IQ. Recently, three sequence variants were shown to associate with educational attainment, a confluence phenotype of genetic and environmental factors contributing to academic success. We show that one of these variants associating with educational attainment, rs4851266-T, also associates with Verbal IQ in dyslexic children (P = 4.3 × 10

Indexed as

CognitionPolymorphism, Single NucleotideAcademic SuccessAdolescentAdultChildChromosomes, Human, Pair 2Databases, GeneticDyslexiaEducational StatusFemaleGenetic MarkersHumansIcelandIntelligenceMaleAFF3 protein, humanGenetic MarkersNuclear Proteins

Identifiers

PMID27811963
PMCPMC5095652

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.