ArticleScientific reports2016
Differential diagnosis of lung cancer, its metastasis and chronic obstructive pulmonary disease based on serum Vegf, Il-8 and MMP-9.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Review
- The multifaceted roles of matrix metalloproteinases in lung cancer.Frontiers in oncology · 2023Review
- A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study.Life (Basel, Switzerland) · 2021Article
- Alkylating and oxidative stresses in smoking and non-smoking patients with COPD: Implications for lung carcinogenesis.Free radical biology & medicine · 2021Article
- Cytokine expression in patients with interstitial lung disease in primary Sjogren's syndrome and its clinical significance.American journal of translational research · 2021Article
- Prognosis of metastasis based on age and serum analytes after follow-up of non-metastatic lung cancer patients.Translational oncology · 2021Article
- Role of TLR4 Receptor Complex in the Regulation of the Innate Immune Response by Fibronectin.Cells · 2020Article
- Fibronectin in the Tumor Microenvironment Activates a TLR4-dependent Inflammatory Response in Lung Cancer Cells.Journal of Cancer · 2020Article
- Article
- Matrix metalloproteinase-9 (MMP-9) Expression in Non-Small Cell Lung Carcinoma and Its Association with Clinicopathologic Factors.Iranian journal of pathology · 2020Article
- Predictive value of a series of inflammatory markers in COPD for lung cancer diagnosis: a case-control study.Respiratory research · 2019Article
- Plasma levels of M-CSF and VEGF in laboratory diagnostics and differentiation of selected histological types of cervical cancers.BMC cancer · 2019Article
- Efficacy of radiotherapy on intermediate and advanced lung cancer and its effect on dynamic changes of serum vascular endothelial growth factor and matrix metalloproteinase-9.Oncology letters · 2018Article
- Serum VEGF levels in the early diagnosis and severity assessment of non-small cell lung cancer.Journal of Cancer · 2018Article
- Article
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9 authors at 3 institutions in 1 country.
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Abstract
Chronic obstructive pulmonary disease (COPD) patients are at higher risk of developing lung cancer and its metastasis, but no suitable biomarker has been reported for differential diagnosis of these patients. Levels of serum biomarkers (VEGF, IL-8, MMP-9 and MMP-2) were analyzed in these patients, which were compared with healthy donors (HD). Levels of VEGF (P < 0.005) and MMP-9 (P < 0.05) were significantly higher in COPD patients than HD. Compared to HD, a decrease in IL-8 (~8.1 folds; P < 0.0001) but an increase in MMP-9 (~1.6 folds; P < 0.05) levels were observed in the lung cancer patients. Cancer patients showed significantly (P < 0.005) lower levels of serum VEGF (1.9 folds) and IL-8 (~9 folds) than the COPD patients. VEGF level was significantly higher (2.6 folds; P < 0.0005) in metastatic than non-metastatic cancer patients. However, MMP-2 didn't show significant variation in these patients. The Youden's index (YI) values for lung cancer diagnosis in HD using IL-8 was 0.55 with 83.3% overall accuracy. VEGF was able to diagnose COPD in HD with better YI (0.38) and overall accuracy (70.6%). IL-8 was able to diagnose cancer in COPD patients and HD with YI values of 0.35, 0.55 with 71% and 83.3% overall accuracy, respectively.
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