Evidence map›Paper›PMID 27811365›Full record

ArticleOncotarget2016

Syntenin-1 is a promoter and prognostic marker of head and neck squamous cell carcinoma invasion and metastasis.

Li Cui, Siliangyu Cheng, Xiaojun Liu, Diana Messadi, Yan Yang, Shen Hu

Open access · diamondAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  11. MiR-31 is a potential biomarker for diagnosis of head and neck squamous cell carcinoma.International journal of clinical and experimental pathology · 2018
    Article
  12. Article
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  14. Reduced serum miR-138 is associated with poor prognosis of head and neck squamous cell carcinoma.International journal of clinical and experimental pathology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Li CuiUniversity of California at Los Angeles, School of Dentistry, Los Angeles, CA 90095, USA.
Siliangyu ChengUniversity of California at Los Angeles, School of Dentistry, Los Angeles, CA 90095, USA.
Xiaojun LiuUniversity of California at Los Angeles, School of Dentistry, Los Angeles, CA 90095, USA.
Diana MessadiUniversity of California at Los Angeles, School of Dentistry, Los Angeles, CA 90095, USA.
Yan YangUniversity of California at Los Angeles, School of Dentistry, Los Angeles, CA 90095, USA.
Shen HuUniversity of California at Los Angeles, School of Dentistry, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USUCLA Jonsson Comprehensive Cancer CenterWuhan University · CN

Funding

Serum Proteome Analysis of Oral Cancer MetastasisR21CA122806 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HU, SHEN · 2007 to 2009
$359k
NCI NIH HHS R21 CA122806
6 · The paper itself

Abstract

Metastasis represents a key factor associated with poor prognosis of head and neck squamous cell carcinoma (HNSC). However, the underlying molecular mechanisms remain largely unknown. In this study, our liquid chromatography with tandem mass spectrometry analysis revealed a number of significantly differentially expressed membrane/membrane-associated proteins between high invasive UM1 and low invasive UM2 cells. One of the identified membrane proteins, Syntenin-1, was remarkably up-regulated in HNSC tissues and cell lines when compared to the controls, and also over-expressed in recurrent HNSC and high invasive UM1 cells. Syntenin-1 over-expression was found to be significantly associated with lymph node metastasis and disease recurrence. HNSC patients with higher syntenin-1 expression had significantly poorer long term overall survival and similar results were found in many other types of cancers based on analysis of The Cancer Genome Atlas data. Finally, knockdown of syntenin-1 inhibited the proliferation, migration and invasion of HNSC cells, and opposite findings were observed when syntenin-1 was over-expressed. Collectively, our studies indicate that syntenin-1 promotes invasion and progression of HNSC. It may serve as a valuable biomarker for lymph node metastasis or a potential target for therapeutic intervention in HNSC.

Indexed as

Cell MovementAgedBiomarkers, TumorCarcinoma, Squamous CellCell Line, TumorCell ProliferationChromatography, LiquidFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalBiomarkers, TumorSDCBP protein, humanSynteninshead and neck squamous cell carcinomamembrane proteinsmetastasissyntenin-1

Identifiers

PMID27811365
PMCPMC5347720
OpenAlexW2547884928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.