Evidence map›Paper›PMID 27811320›Full record

ArticleThe Journal of infectious diseases2017

Cross-Reactive and Cross-Neutralizing Activity of Human Mumps Antibodies Against a Novel Mumps Virus From Bats.

Shannon M Beaty, Raffael Nachbagauer, Ariana Hirsh, Frederic Vigant, James Duehr, Kristopher D Azarm, Alice J Stelfox, Thomas A Bowden, W Paul Duprex, Florian Krammer and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Shannon M BeatyDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York.
Raffael NachbagauerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York.
Ariana HirshDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York.
Frederic VigantDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York.
James DuehrDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York.
Kristopher D AzarmDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York.
Alice J StelfoxDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
Thomas A BowdenDivision of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, United Kingdom.
W Paul DuprexDepartment of Microbiology, Boston University School of Medicine, Massachusetts.
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York.
Benhur LeeDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York.
Icahn School of Medicine at Mount Sinai · USBoston University · USCentre for Human Genetics · GBUniversity of Oxford · GB

Funding

TRAINING PROGRAM: MECHANISMS OF VIRUS-HOST INTERACTIONST32AI007647 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Domenico Tortorella · 2000 to 2026
$11.5M
Tropism, pathogenicity, and potential for zoonotic spillover of emergent henipa- and henipa-like virusesR01AI123449 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, BENHUR · 2016 to 2020
$2.7M
Shifting a Paradigm in Vaccine Safety: From Empirical to Rational AttenuationR01AI099100 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DUPREX, WILLIAM PAUL · 2013 to 2017
$2.0M
Functional interrogation of paramyxovirus genomes with efficient reverse geneticsR21AI115226 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LEE, BENHUR · 2015 to 2016
$460k
Medical Research Council MR/L009528/1NIAID NIH HHS R01 AI099100NIAID NIH HHS R01 AI123449NIAID NIH HHS R21 AI115226NIAID NIH HHS T32 AI007647
6 · The paper itself

Abstract

To evaluate the antigenic relationship between bat mumps virus (BMV) and the JL5 vaccine strain of mumps virus (MuVJL5), we rescued a chimeric virus bearing the F and HN glycoproteins of BMV in the background of a recombinant JL5 genome (rMuVJL5). Cross-reactivity and cross-neutralization between this chimeric recombinant MuV bearing the F and HN glycoproteins of BMV (rMuVJL5-F/HNBMV) virus and rMuVJL5 were demonstrated using hyperimmune mouse serum samples and a curated panel of human serum. All mouse and human serum samples that were able to neutralize rMuVJL5 infection had cross-neutralizing activity against rMuVJL5-F/HNBMV. Our data suggest that persons who have neutralizing antibodies against MuV might be protected from infection by BMV.

Indexed as

Cross ReactionsAdolescentAdultAnimalsAntibodies, NeutralizingAntibodies, ViralChiropteraFemaleHumansMice, Inbred BALB CMiddle AgedMumps virusYoung AdultAntibodies, NeutralizingAntibodies, Viralcross-reactive antibodiesmumps virusneutralizing antibodiesviral envelope proteinszoonoses

Identifiers

PMID27811320
PMCPMC5854012
OpenAlexW2546584100

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.