ArticleJournal of Crohn's & colitis2017
Fungal Microbiota Profile in Newly Diagnosed Treatment-naïve Children with Crohn's Disease.
Article in Journal of Crohn's & colitis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Gut Mycobiome in Inflammatory Bowel Disease: A Systematic Review of Case-Control Studies.Inflammatory bowel diseases · 2025Pooled it
- Saudi consensus guidance for the diagnosis and management of inflammatory bowel disease in children and adolescents.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025Guideline
- Oral Microbiota and Inflammatory Bowel Diseases: Detection of Emerging Fungal Pathogens and Herpesvirus.Biomedicines · 2025Article
- Unveiling the fungal frontier: mycological insights into inflammatory bowel disease.Frontiers in immunology · 2025Review
- Gut fungal profile in new onset treatment-naïve ulcerative colitis in Saudi children.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025Article
- Shotgun metagenomics reveals interkingdom association between intestinal bacteria and fungi involving competition for nutrients.Microbiome · 2023Article
- Candida spp. in Human Intestinal Health and Disease: More than a Gut Feeling.Mycopathologia · 2023Review
- Alteration of Colonic Bacterial and Fungal Composition and Their Inter- and Intra-Kingdom Interaction in Patients with Adenomas with Low-Grade Dysplasia.Microorganisms · 2023Article
- The eukaryome of African children is influenced by geographic location, gut biogeography, and nutritional status.microLife · 2023Article
- Exclusive Enteral Nutrition Exerts Anti-Inflammatory Effects through Modulating Microbiota, Bile Acid Metabolism, and Immune Activities.Nutrients · 2022Article
- Mycobiota composition and changes across pregnancy in patients with gestational diabetes mellitus (GDM).Scientific reports · 2022Article
- Gut mycobiome dysbiosis in rats showing retinal changes indicative of diabetic retinopathy.PloS one · 2022Article
- Fungal Dysbiosis in Children with Celiac Disease.Digestive diseases and sciences · 2022Article
- The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course.Frontiers in medicine · 2022Article
- Therapeutic potential of an intestinotrophic hormone, glucagon-like peptide 2, for treatment of type 2 short bowel syndrome rats with intestinal bacterial and fungal dysbiosis.BMC infectious diseases · 2021Article
- The role of gut mycobiome in health and diseases.Therapeutic advances in gastroenterology · 2021Review
- Gut mycobiomes are altered in people with type 2 Diabetes Mellitus and Diabetic Retinopathy.PloS one · 2020Article
- Putative Pathobionts in HLA-B27-Associated Spondyloarthropathy.Frontiers in immunology · 2020Review
- Characterization of fungal and bacterial dysbiosis in young adult Chinese patients with Crohn's disease.Therapeutic advances in gastroenterology · 2020Article
- The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases.Nature reviews. Gastroenterology & hepatology · 2019Review
Corrections and comments
- Expression of concern · 2022-01-24Civil Proceedings · Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Legal Reasons and/or Threats · · See also: https://doi.org/10.1093/ecco-jcc/jjab225 Journal was previously published by Elsevier until 2015.
- Commented on by
- Erratum issuedCorrection.2023
Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Although increasing evidence suggests a role for fungi in inflammatory bowel disease [IBD], data are scarce and mostly from adults. Our aim was to define the characteristics of fungal microbiota in newly diagnosed treatment-naïve children with Crohn's disease [CD]. Methods: The children referred for colonoscopy were prospectively enrolled in the study at King Khalid University Hospital, King Saud University, and Al Mofarreh Polyclinics in Riyadh. Tissue and stool samples were collected and frozen till sequencing analysis. The children with confirmed CD diagnosis were designated as cases and the others as non- IBD controls; 78 samples were collected from 35 children [15 CD and 20 controls]. Statistical analysis was performed to investigate CD associations and diversity. Results: CD-associated fungi varied with the level of phylogenetic tree. There was no significant difference in abundance between normal and inflamed mucosa. Significantly abundant CD-associated taxa included Psathyrellaceae [p = 0.01], Cortinariaceae [p = 0.04], Psathyrella [p = 0.003], and Gymnopilus [p = 0.03]. Monilinia was significantly depleted [p = 0.03], whereas other depleted taxa, although not statistically significant, included Leotiomycetes [p = 0.06], Helotiales [p = 0.08], and Sclerotiniaceae [p = 0.07]. There was no significant difference in fungal diversity between CD and controls. Conclusions: We report highly significant fungal dysbiosis in newly diagnosed treatment-naïve CD children. Depleted and more abundant taxa suggest anti-inflammatory and pro-inflamatory potentials, respectively. Further studies with larger sample size and including functional analysis are needed to clarify the significance of the fungal community in the pathogenesis of CD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.