ArticleGenome biology and evolution2016
Study of Gene Trafficking between Acanthamoeba and Giant Viruses Suggests an Undiscovered Family of Amoeba-Infecting Viruses.
Article in Genome biology and evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- The Implication of Horizontal Gene Transfer BetweenPathogens (Basel, Switzerland) · 2026Pooled it
- Genome-wide Characterization of Non-shared Sequences among Amphora-shaped Giant Viruses.Microbes and environments · 2026Article
- Persistent mirusvirus infection in the marine protist Aurantiochytrium.Nature communications · 2025Article
- Epigenetic silencing and genome dynamics determine the fate of giant virus endogenizations in Acanthamoeba.BMC biology · 2025Article
- 20 years of research on giant viruses.Npj viruses · 2025Review
- Co-infection of phylogenetically distinct nucleocytoviruses in Acanthamoeba castellanii cells.FEMS microbiology letters · 2025Article
- Novel High-Quality Amoeba Genomes Reveal Widespread Codon Usage Mismatch Between Giant Viruses and Their Hosts.Genome biology and evolution · 2025Article
- The GC% landscape of the Nucleocytoviricota.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- DNA methylation enables recurrent endogenization of giant viruses in an animal relative.Science advances · 2024Article
- Massive intein content inProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genomic adaptation of giant viruses in polar oceans.Nature communications · 2023Article
- Omics of an Enigmatic Marine Amoeba Uncovers Unprecedented Gene Trafficking from Giant Viruses and Provides Insights into Its Complex Life Cycle.Microbiology research · 2023Article
- Large-scale invasion of unicellular eukaryotic genomes by integrating DNA viruses.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A 1.5-Mb continuous endogenous viral region in the arbuscular mycorrhizal fungusVirus evolution · 2023Article
- Giant virus biology and diversity in the era of genome-resolved metagenomics.Nature reviews. Microbiology · 2022Review
- Viral Complexity.Biomolecules · 2022Review
- A Comparative Genomic Approach to Determine the Virulence Factors and Horizontal Gene Transfer Events of Clinical Acanthamoeba Isolates.Microbiology spectrum · 2022Article
- Systematic evaluation of horizontal gene transfer between eukaryotes and viruses.Nature microbiology · 2022Article
- Integrated viral elements suggest the dual lifestyle ofVirus evolution · 2022Article
- Commensals Serve as Natural Barriers to Mammalian Cells during Acanthamoeba castellanii Invasion.Microbiology spectrum · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nucleocytoplasmic large DNA viruses (NCLDV) are a group of extremely complex double-stranded DNA viruses, which are major parasites of a variety of eukaryotes. Recent studies showed that certain unicellular eukaryotes contain fragments of NCLDV DNA integrated in their genome, when surprisingly many of these organisms were not previously shown to be infected by NCLDVs. These findings prompted us to search the genome of Acanthamoeba castellanii strain Neff (Neff), one of the most prolific hosts in the discovery of giant NCLDVs, for possible DNA inserts of viral origin. We report the identification of 267 markers of lateral gene transfer with viruses, approximately half of which are clustered in Neff genome regions of viral origins, transcriptionally inactive or exhibit nucleotide-composition signatures suggestive of a foreign origin. The integrated viral genes had diverse origin among relatives of viruses that infect Neff, including Mollivirus, Pandoravirus, Marseillevirus, Pithovirus, and Mimivirus However, phylogenetic analysis suggests the existence of a yet-undiscovered family of amoeba-infecting NCLDV in addition to the five already characterized. The active transcription of some apparently anciently integrated virus-like genes suggests that some viral genes might have been domesticated during the amoeba evolution. These insights confirm that genomic insertion of NCLDV DNA is a common theme in eukaryotes. This gene flow contributed fertilizing the eukaryotic gene repertoire and participated in the occurrence of orphan genes, a long standing issue in genomics. Search for viral inserts in eukaryotic genomes followed by environmental screening of the original viruses should be used to isolate radically new NCLDVs.
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