Evidence map›Paper›PMID 27811173›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2017

An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis.

Kjell A Svensson, Beverly A Heinz, John M Schaus, James P Beck, Junliang Hao, Joseph H Krushinski, Matthew R Reinhard, Michael P Cohen, Sarah L Hellman, Brian G Getman and 22 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. The Signaling and Pharmacology of the Dopamine D1 Receptor.Frontiers in cellular neuroscience · 2021
    Pooled it
  2. Safety and Efficacy of Mevidalen in Lewy Body Dementia: A Phase 2, Randomized, Placebo-Controlled Trial.Movement disorders : official journal of the Movement Disorder Society · 2022
    Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 3 institutions in 1 country.

Kjell A SvenssonLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.) svensson_kjell_a@lilly.com.
Beverly A HeinzLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
John M SchausLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
James P BeckLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Junliang HaoLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Joseph H KrushinskiLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Matthew R ReinhardLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Michael P CohenLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Sarah L HellmanLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Brian G GetmanLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Xushan WangLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Michelle M MenezesLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Deanna L MarenLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Julie F FalconeLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Wesley H AndersonLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Rebecca A WrightLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
S Michelle MorinLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Kelly L KnoppLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Benjamin L AdamsLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Borys RogovoyLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Ilya OkunLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Todd M SuterLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Michael A StatnickLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Donald R GehlertLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
David L NelsonLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Virginia L LucaitesLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Renee EmkeyLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Neil W DeLappLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Todd R WiernickiLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Jeffrey W CramerLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Charles R YangLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
Robert F BrunsLilly Research Laboratories, Eli Lilly & Co., Indianapolis, Indiana (K.A.S., B.A.H., J.M.S., J.P.B., J.H., J.H.K., M.R.R., M.P.C., S.L.H., B.G.G., X.W., M.M.M., D.L.M., J.F.F., W.H.A., R.A.W., S.M.M., K.L.K., B.L.A., T.M.S., M.A.S., D.R.G., D.L.N., V.L.L., R.E., N.W.D., T.R.W., J.W.C., C.R.Y., R.F.B.); Chemical Diversity, Inc., San Diego, California (B.R., I.O.).
ChemDiv (United States) · USEli Lilly (United States) · USOffice of Diversity and Inclusion · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allosteric potentiators amplify the sensitivity of physiologic control circuits, a mode of action that could provide therapeutic advantages. This hypothesis was tested with the dopamine D1 receptor potentiator DETQ [2-(2,6-dichlorophenyl)-1-((1S,3R)-3-(hydroxymethyl)-5-(2-hydroxypropan-2-yl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl)ethan-1-one]. In human embryonic kidney 293 (HEK293) cells expressing the human D1 receptor, DETQ induced a 21-fold leftward shift in the cAMP response to dopamine, with a K

Indexed as

Gene Knock-In TechniquesTachyphylaxisAdamantaneAllosteric RegulationAnimalsBehavior, AnimalBenzopyransDose-Response Relationship, DrugFemaleHEK293 CellsHumansIsoquinolinesLocomotionMaleMiceProtein TransportA 77636AdamantaneBenzopyransDETQ compoundisoquinolineIsoquinolinesReceptors, Dopamine D1

Identifiers

PMID27811173
PMCPMC5193077
OpenAlexW2547430990

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