ArticleJournal of experimental botany2016
The ratio of Zn to Cd supply as a determinant of metal-homeostasis gene expression in tobacco and its modulation by overexpressing the metal exporter AtHMA4.
Article in Journal of experimental botany, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Zinc translocation from Zn-sufficient to Zn-deficient roots as an adaptation to heterogeneous Zn availability.BMC plant biology · 2025Article
- Transfer and transformation characteristics of Zn and Cd in soil-rotation plant (Brassica napus L and Oryza sativa L) system and its influencing factors.Scientific reports · 2023Article
- Tobacco as an efficient metal accumulator.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
- Proteome Analysis ofPlants (Basel, Switzerland) · 2023Article
- Metal Tolerance Protein Encoding Gene Family inPlants (Basel, Switzerland) · 2022Article
- Suppression ofInternational journal of molecular sciences · 2021Article
- Combined cadmium-zinc interactions alter manganese, lead, copper uptake by Melissa officinalis.Scientific reports · 2020Article
- Zn/Cd status-dependent accumulation of Zn and Cd in root parts in tobacco is accompanied by specific expression of ZIP genes.BMC plant biology · 2020Article
- Recent Trends in Enhancing the Resistance of Cultivated Plants to Heavy Metal Stress by Transgenesis and Transcriptional Programming.Molecular biotechnology · 2019Review
- A feedback loop between CaWRKY41 and H2O2 coordinates the response to Ralstonia solanacearum and excess cadmium in pepper.Journal of experimental botany · 2019Article
- Contribution of NtZIP1-Like to the Regulation of Zn Homeostasis.Frontiers in plant science · 2018Article
- Functional Analysis ofFrontiers in plant science · 2018Article
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Authors and funding
7 authors.
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Abstract
This study links changes in the tobacco endogenous metal-homeostasis network caused by transgene expression with engineering of novel features. It also provides insight into the concentration-dependent mutual interactions between Zn and Cd, leading to differences in the metal partitioning between wild-type and transgenic plants. In tobacco, expression of the export protein AtHMA4 modified Zn/Cd root/shoot distribution, but the pattern depended on their concentrations in the medium. To address this phenomenon, the expression of genes identified by suppression subtractive hybridization and the Zn/Cd accumulation pattern were examined upon exposure to six variants of low/high Zn and Cd concentrations. Five tobacco metal-homeostasis genes were identified: NtZIP2, NtZIP4, NtIRT1-like, NtNAS, and NtVTL. In the wild type, their expression depended on combinations of low/high Zn and Cd concentrations; co-ordinated responses of NtZIP1, NtZIP2, and NtVTL were shown in medium containing 4 µM Cd, and at 0.5 µM versus 10 µM Zn. In transgenics, qualitative changes detected for NtZIP1, NtZIP4, NtIRT1-like, and NtVTL are considered crucial for modification of Zn/Cd supply-dependent Zn/Cd root/shoot distribution. Notwithstanding, NtVTL was the most responsive gene in wild-type and transgenic plants under all concentrations of Zn and Cd tested; thus it is a candidate gene for the regulation of metal cross-homeostasis processes involved in engineering new metal-related traits.
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