ArticleJournal of experimental botany2016
Tomato HAIRY MERISTEM genes are involved in meristem maintenance and compound leaf morphogenesis.
Article in Journal of experimental botany, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Identification of miR171a-International journal of molecular sciences · 2025Article
- "Bud to bloom"-hormonal coordination in floral initiation.Plant biology (Stuttgart, Germany) · 2025Review
- Tomato HAIRY MERISTEM4, expressed in the phloem, is required for proper shoot and fruit development.Horticulture research · 2025Article
- Functions and Regulation of HAM Family Genes in Meristems During Gametophyte and Sporophyte Generations.Plant, cell & environment · 2025Review
- Morphological characterization and transcriptome analysis of rolled and narrow leaf mutant in soybean.BMC plant biology · 2024Article
- Genome-Wide Identification of GRAS Transcription Factors and Their Functional Analysis in Salt Stress Response in Sugar Beet.International journal of molecular sciences · 2024Article
- Overexpression of LarchPlants (Basel, Switzerland) · 2024Article
- Overexpression of miR390b promotes stem elongation and height growth inHorticulture research · 2023Article
- Role of microRNA miR171 in plant development.PeerJ · 2023Review
- Tomato MicroRNAs and Their Functions.International journal of molecular sciences · 2022Review
- Article
- Illuminating the molecular mechanisms underlying shoot apical meristem homeostasis in plants.Plant biotechnology (Tokyo, Japan) · 2022Article
- Function and Regulation of microRNA171 in Plant Stem Cell Homeostasis and Developmental Programing.International journal of molecular sciences · 2022Review
- CRISPR/Cas9 mutants of tomato MICRORNA164 genes uncover their functional specialization in development.Plant physiology · 2021Article
- PpGRAS12 acts as a positive regulator of meristem formation in Physcomitrium patens.Plant molecular biology · 2021Article
- The diverse roles of cytokinins in regulating leaf development.Horticulture research · 2021Review
- Tomato agamous-like6 parthenocarpy is facilitated by ovule integument reprogramming involving the growth regulator KLUH.Plant physiology · 2021Article
- A De Novo Transcriptome Assembly of Ceratopteris richardii Provides Insights into the Evolutionary Dynamics of Complex Gene Families in Land Plants.Genome biology and evolution · 2021Article
- Review
- Genome-wide identification of GRAS genes in Brachypodium distachyon and functional characterization of BdSLR1 and BdSLRL1.BMC genomics · 2019Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The HAIRY MERISTEM (HAM) genes function in meristem maintenance but play minor roles in the morphogenesis of a simple leaf that is determinate. Here, we functionally analyzed HAM genes in tomato and uncovered their involvement in compound leaf morphogenesis. Tomato encodes three HAM homologs, of which SlHAM and SlHAM2 (SlHAMs) are guided for cleavage by microRNA171 and are abundant in the shoot and floral meristems as well as in the compound leaf primordia. We found that SlHAMs silencing led to overproliferation of cells in the periphery of the meristems where SlHAM is localized. As in meristems, leaf-specific silencing of SlHAMs provoked overproliferation of meristematic cells in the organogenic compound leaf rachis. We further demonstrate that the meristematic cell overproliferation in both meristems and leaves was in part due to the misexpression of the stem cell regulator WUSCHEL, previously shown to be induced by cytokinin. Strikingly, reduction of cytokinin levels in SlHAMs-silenced leaves completely suppressed the overproliferation phenotype, suggesting a regulatory link between SlHAMs and cytokinin, a key hormone found to promote indeterminacy in meristems and leaves. Taken together, our data provide evidence that in addition to their conserved function in meristem maintenance, SlHAMs are also required for the proper morphogenesis of the compound leaf.
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