Evidence map›Paper›PMID 27811060›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2017

IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle.

Sezin Dagdeviren, Dae Young Jung, Randall H Friedline, Hye Lim Noh, Jong Hun Kim, Payal R Patel, Nicholas Tsitsilianos, Kunikazu Inashima, Duy A Tran, Xiaodi Hu and 5 more

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sezin DagdevirenDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Dae Young JungDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Randall H FriedlineDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Hye Lim NohDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jong Hun KimDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Payal R PatelDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Nicholas TsitsilianosDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Kunikazu InashimaDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Duy A TranDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Xiaodi HuDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Marilia M LoubatoDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Siobhan M CraigeDivision of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jung Yeon KwonDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Ki Won LeeDepartment of Agricultural Biotechnology, Seoul National University, Seoul, South Korea; and.
Jason K KimDepartment of Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA; jason.kim@umassmed.edu.

Funding

Systems Biology of Insulin ResistanceR24DK090963 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI DAVIS, ROGER J. · 2011 to 2014
$8.4M
UMass Mouse Metabolic Phenotyping Center - Metabolism CoreU2CDK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2016 to 2021
$4.6M
UMass Mouse Metabolic Phenotyping CenterU24DK093000 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2011 to 2015
$2.1M
Interleukin-10 and Regulation of Skeletal Muscle Insulin ActionR01DK080756 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI KIM, JASON K · 2008 to 2012
$1.6M
Endoplasmic Reticulum Chaperone as a Regulator of Obesity and DiabetesR01DK079999 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, AMY S · 2009 to 2010
$776k
NIDDK NIH HHS R01 DK079999NIDDK NIH HHS R01 DK080756NIDDK NIH HHS R24 DK090963NIDDK NIH HHS U24 DK093000NIDDK NIH HHS U2C DK093000
6 · The paper itself

Abstract

Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (M

Indexed as

AgingAnimalsCreatine Kinase, MM FormEnergy MetabolismInflammationInsulin ResistanceInterleukin-10MaleMiceMice, TransgenicMuscle, SkeletalCreatine Kinase, MM FormInterleukin-10agingcytokinesglucose metabolisminterleukinstype 2 diabetes

Identifiers

PMID27811060
PMCPMC5240661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.