Evidence map›Paper›PMID 27811008›Full record

ArticleBMJ (Clinical research ed.)2016

Vasectomy and risk of prostate cancer: population based matched cohort study.

Madhur Nayan, Robert J Hamilton, Erin M Macdonald, Qing Li, Muhammad M Mamdani, Craig C Earle, Girish S Kulkarni, Keith A Jarvi, David N Juurlink, Canadian Drug Safety and Effectiveness Research Network (CDSERN)

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ (Clinical research ed.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
9.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Review of Vasectomy Complications and Safety Concerns.The world journal of men's health · 2021
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Madhur NayanDivision of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, 610 University Ave 3-130, Toronto, ON, M5G 2M9, Canada madhur.nayan@mail.utoronto.ca.
Robert J HamiltonDivision of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, 610 University Ave 3-130, Toronto, ON, M5G 2M9, Canada.
Erin M MacdonaldInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Qing LiInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Muhammad M MamdaniInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Craig C EarleInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Girish S KulkarniDivision of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Centre, University Health Network and the University of Toronto, 610 University Ave 3-130, Toronto, ON, M5G 2M9, Canada.
Keith A JarviDivision of Urology, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada; Faculty of Medicine, Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Lunenfeld Tannenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.
David N JuurlinkInstitute for Clinical Evaluative Sciences, Toronto, ON, Canada.
Canadian Drug Safety and Effectiveness Research Network (CDSERN)
Institute for Clinical Evaluative Sciences · CAUniversity of Toronto · CAMount Sinai Hospital · CAOntario Institute for Cancer Research · CAPrincess Margaret Cancer Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the association between vasectomy and prostate cancer, adjusting for measures of health seeking behaviour.

designPopulation based matched cohort study.

settingMultiple validated healthcare databases in Ontario, Canada, 1994-2012.

participants326 607 men aged 20 to 65 who had undergone vasectomy were identified through physician billing codes and matched 1:1 on age (within two years), year of cohort entry, comorbidity score, and geographical region to men who did not undergo a vasectomy. MAIN OUTCOMES MEASURES: The primary outcome was incident prostate cancer. Secondary outcomes were prostate cancer related grade, stage, and mortality.

results3462 incident cases of prostate cancer were identified after a median follow-up of 10.9 years: 1843 (53.2%) in the vasectomy group and 1619 (46.8%) in the non-vasectomy group. In unadjusted analysis, vasectomy was associated with a slightly increased risk of incident prostate cancer (hazard ratio 1.13, 95% confidence interval 1.05 to 1.20). After adjustment for measures of health seeking behaviour, however, no association remained (adjusted hazard ratio 1.02, 95% confidence interval 0.95 to 1.09). Moreover, no association was found between vasectomy and high grade prostate cancer (adjusted odds ratio 1.05, 95% confidence interval 0.67 to 1.66), advanced stage prostate cancer (adjusted odds ratio 1.04, 0.81 to 1.34), or mortality (adjusted hazard ratio 1.06, 0.60 to 1.85).

conclusionThe findings do not support an independent association between vasectomy and prostate cancer.

Indexed as

AdultAgedCohort StudiesHumansIncidenceMaleMatched-Pair AnalysisMiddle AgedOntarioProstatic NeoplasmsVasectomyYoung Adult

Identifiers

PMID27811008
PMCPMC5094198
OpenAlexW2548729789

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.