Evidence map›Paper›PMID 27810966›Full record

ArticleJournal of child neurology2017

Brainstem Low-Grade Gliomas in Children-Excellent Outcomes With Multimodality Therapy.

Santhosh A Upadhyaya, Carl Koschmann, Karin Muraszko, Sriram Venneti, Hugh J Garton, Daniel A Hamstra, Cormac O Maher, Bryan L Betz, Noah A Brown, Daniel Wahl and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of child neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Pediatric low-grade brainstem glioma: a review of current diagnosis and treatment paradigms in the molecular era.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Pooled it
  2. Article
  3. Article
  4. Benign brainstem tumors in children: a retrospective series of 42 patients treated in Lyon.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
    Article
  5. Role of surgery in the treatment of pediatric low-grade glioma with various degrees of brain stem involvement.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Article
  6. Review
  7. Contemporary Management of Pediatric Brainstem Tumors.Advances and technical standards in neurosurgery · 2024
    Review
  8. Article
  9. Management and outcome of pediatric brainstem and cerebellar peduncular low-grade gliomas: a retrospective analysis of 62 cases.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Santhosh A Upadhyaya1 Department of Oncology, Division of Neuro-Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Carl Koschmann2 Department of Pediatrics, Division of Pediatric Hematology Oncology, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
Karin Muraszko3 Department of Neurosurgery, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
Sriram Venneti4 Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Hugh J Garton3 Department of Neurosurgery, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
Daniel A Hamstra5 Texas Center for Proton Therapy, Irving, TX, USA.
Cormac O Maher3 Department of Neurosurgery, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
Bryan L Betz4 Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Noah A Brown4 Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Daniel Wahl6 Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA.
Helmut C Weigelin4 Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Kathleen E DuRoss4 Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Annette S Leonard4 Department of Pathology, University of Michigan, Ann Arbor, MI, USA.
Patricia L Robertson2 Department of Pediatrics, Division of Pediatric Hematology Oncology, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USC. S. Mott Children's Hospital · USSt. Jude Children's Research Hospital · US

Funding

Targeting ATRX-Deficient Pediatric GBMK08NS099427 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOSCHMANN, CARL J · 2017 to 2021
$811k
NINDS NIH HHS K08 NS099427
6 · The paper itself

Abstract

Safe maximal surgical resection is the initial treatment of choice for pediatric brainstem low-grade gliomas. Optimal therapy for incompletely resected tumors or that progress after surgery is uncertain. We reviewed the clinical characteristics, therapy, and outcomes of all children with nontectal brainstem low-grade gliomas treated at the University of Michigan between 1993 and 2013. Median age at diagnosis was 6 years; histology was confirmed in 23 of 25 tumors, 64% were pilocytic astrocytoma. Nineteen patients underwent initial tumor resection; 14/19 received no upfront adjuvant therapy. Eight patients in the study had progressive disease; 5 initially resected tumors received chemotherapy at tumor relapse, all with partial or complete radiographic responses. Ten-year progression-free survival is 71% and overall survival, 100%. This single-institution retrospective study demonstrates excellent survival rates for children with brainstem low-grade gliomas. The efficacy of the well-tolerated chemotherapy in this series supports its role in the treatment of unresectable or progressive brainstem low-grade gliomas.

Indexed as

AdolescentBrain Stem NeoplasmsChildChild, PreschoolCombined Modality TherapyDisease-Free SurvivalFemaleFollow-Up StudiesGliomaHumansInfantMaleProto-Oncogene Proteins B-rafRetrospective StudiesTreatment OutcomeBRAF protein, humanProto-Oncogene Proteins B-rafbrainstem tumorschemotherapylow-grade gliomaoverall survivalprogressive tumors

Identifiers

PMID27810966
PMCPMC5582383
OpenAlexW2548056833

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.