ArticlePlant physiology2016
Methyl Transfer in Glucosinolate Biosynthesis Mediated by Indole Glucosinolate O-Methyltransferase 5.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
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- Ectopic Gene Conversion Causing Quantitative Trait Variation.Molecular biology and evolution · 2025Article
- Polyploids of Brassicaceae: Genomic Insights and Assembly Strategies.Plants (Basel, Switzerland) · 2024Review
- Aphid Resistance Segregates Independently of Cardenolide and Glucosinolate Content in anPlants (Basel, Switzerland) · 2024Article
- Natural genetic variation and negative density effects in plant-nematode interactions.Plant-environment interactions (Hoboken, N.J.) · 2024Article
- Aphid resistance segregates independently of cardiac glycoside and glucosinolate content in anbioRxiv : the preprint server for biology · 2024Article
- Glucosinolate O-methyltransferase mediated callus formation and affected ROS homeostasis inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Selenium Biofortification Effect on Glucosinolate Content ofMolecules (Basel, Switzerland) · 2023Article
- The allotetraploid horseradish genome provides insights into subgenome diversification and formation of critical traits.Nature communications · 2023Article
- Developing multifunctional crops by engineering Brassicaceae glucosinolate pathways.Plant communications · 2023Review
- The Engagement of Cytochrome P450 Enzymes in Tryptophan Metabolism.Metabolites · 2023Review
- Transcriptomic Analysis of Heat Stress Response inInternational journal of molecular sciences · 2023Article
- Glucosinolates and Cytotoxic Activity of Collard Volatiles Obtained Using Microwave-Assisted Extraction.Molecules (Basel, Switzerland) · 2023Article
- Genome-Wide Association Study of Glucosinolate Metabolites (mGWAS) inPlants (Basel, Switzerland) · 2023Article
- Glucosinolates ofMolecules (Basel, Switzerland) · 2022Article
- Specialist root herbivore modulates plant transcriptome and downregulates defensive secondary metabolites in a brassicaceous plant.The New phytologist · 2022Article
- Genome-wide association mapping within a localPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- First experimental evidence suggests use of glucobrassicin as source of auxin in drought-stressedFrontiers in plant science · 2022Article
- Multiple indole glucosinolates and myrosinases defend Arabidopsis against Tetranychus urticae herbivory.Plant physiology · 2021Article
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Authors and funding
8 authors at 1 institution in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indole glucosinolates (IGs) are plant secondary metabolites that are derived from the amino acid tryptophan. The product of Arabidopsis (Arabidopsis thaliana) IG core biosynthesis, indol-3-ylmethyl glucosinolate (I3M), can be modified by hydroxylation and subsequent methoxylation of the indole ring in position 1 (1-IG modification) or 4 (4-IG modification). Products of the 4-IG modification pathway mediate plant-enemy interactions and are particularly important for Arabidopsis innate immunity. While CYP81Fs encoding cytochrome P450 monooxygenases and IGMTs encoding indole glucosinolate O-methyltransferases have been identified as key genes for IG modification, our knowledge about the IG modification pathways is not complete. In particular, it is unknown which enzyme is responsible for methyl transfer in the 1-IG modification pathway and whether this pathway plays a role in defense, similar to 4-IG modification. Here, we analyze two Arabidopsis transfer DNA insertion lines with targeted metabolomics. We show that biosynthesis of 1-methoxyindol-3-ylmethyl glucosinolate (1MOI3M) from I3M involves the predicted unstable intermediate 1-hydroxyindol-3-ylmethyl glucosinolate (1OHI3M) and that IGMT5, a gene with moderate similarity to previously characterized IGMTs, encodes the methyltransferase that is responsible for the conversion of 1OHI3M to 1MOI3M. Disruption of IGMT5 function increases resistance against the root-knot nematode Meloidogyne javanica and suggests a potential role for the 1-IG modification pathway in Arabidopsis belowground defense.
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