Evidence map›Paper›PMID 27810899›Full record

ArticleThe Journal of biological chemistry2016

A Pitcher-and-Catcher Mechanism Drives Endogenous Substrate Isomerization by a Dehydrogenase in Kynurenine Metabolism.

Yu Yang, Ian Davis, Uyen Ha, Yifan Wang, Inchul Shin, Aimin Liu

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Observing 3-hydroxyanthranilate-3,4-dioxygenase in action through a crystalline lens.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yu YangFrom the Department of Chemistry, University of Texas, San Antonio, Texas 78249 and.
Ian DavisFrom the Department of Chemistry, University of Texas, San Antonio, Texas 78249 and.
Uyen Hathe Department of Chemistry, Georgia State University, Atlanta, Georgia 30303.
Yifan WangFrom the Department of Chemistry, University of Texas, San Antonio, Texas 78249 and.
Inchul ShinFrom the Department of Chemistry, University of Texas, San Antonio, Texas 78249 and.
Aimin LiuFrom the Department of Chemistry, University of Texas, San Antonio, Texas 78249 and Feradical@utsa.edu.ORCID http://orcid.org/0000-0002-4182-8176
Georgia State University · USThe University of Texas at San Antonio · US

Funding

Kynurenine metabolites and depression: An in vitro and ex vivo studyR21MH107985 · NIMH · UNIVERSITY OF TEXAS SAN ANTONIO · PI LIU, AIMIN, SHAMSI, SHAHAB AHMED · 2016 to 2017
$420k
NIMH NIH HHS R21 MH107985
6 · The paper itself

Abstract

Aldehyde dehydrogenase typically performs oxidation of aldehydes to their corresponding carboxylic acid while reducing NAD(P)

Indexed as

Amino Acid SubstitutionBacterial ProteinsKynurenineMutation, MissenseNADOxidoreductasesPseudomonas fluorescensBacterial ProteinsKynurenineNADOxidoreductasesbifunctional enzymebiodegradationcrystal structuredecarboxylasedehydrogenaseenzyme mechanismenzyme structureisomerizationkynureninemetabolic pathwaytryptophan

Identifiers

PMID27810899
PMCPMC5159489
OpenAlexW2546543590

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.