ArticleJournal of affective disorders2017
Sleep architecture parameters as a putative biomarker of suicidal ideation in treatment-resistant depression.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Boulevard of broken rhythms: A systematic review and meta-analysis on the relationship between sleep disturbances and suicidal behavior in bipolar disorder.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Objective measurement of sleep, heart rate, heart rate variability, and physical activity in suicidality: A systematic review.Journal of affective disorders · 2020Pooled it
- Systematic review and meta-analysis of the relationship between sleep disorders and suicidal behaviour in patients with depression.BMC psychiatry · 2019Pooled it
- Examining fronto-limbic brain and sleep mechanisms of antidepressant effects in cognitive-behavioral therapy for insomnia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Impact of an internet-based insomnia intervention on suicidal ideation and associated correlates in veterans at elevated suicide risk.Translational behavioral medicine · 2024Trial
- Polymorphism A118G of opioid receptor mu 1 (OPRM1) is associated with emergence of suicidal ideation at antidepressant onset in a large naturalistic cohort of depressed outpatients.Scientific reports · 2019Trial
- Remote Longitudinal Tracking of Sleep, Depression, and Cognition Across Early Adolescence: Protocol for a Longitudinal Observational Study.JMIR research protocols · 2026Article
- Sleep in Bipolar Disorder: A Systematic Review and Meta-Analysis of Case-Control Drug-Free Patients.Brain sciences · 2026Review
- Postpartum depressive symptoms: the role of time perspective in early pregnancy.BMC psychiatry · 2026Article
- Serum BDNF, depressive symptoms, sleep quality, and cognitive function: a study on their impact and predictive value for suicidal ideation in bipolar depressive disorder patients.European archives of psychiatry and clinical neuroscience · 2026Article
- Association between objective sleep structure and suicidal ideation in patients with depression: a study based on polysomnographic regression and cluster analysis.Frontiers in psychiatry · 2026Article
- Understanding Latine disparities in nocturnal wakefulness as a suicide risk factor.Sleep epidemiology · 2025Article
- Suicidal risk among adolescent psychiatric inpatients: the role of insomnia, depression, and social-personal factors.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Cortical activation during the verbal fluency task for obstructive sleep apnea patients with depressive symptoms: A multi-channel fNIRS study.Brain and behavior · 2024Article
- Sleep Disturbance and Subsequent Suicidal Behaviors in Preadolescence.JAMA network open · 2024Article
- Artificial intelligence assisted tools for the detection of anxiety and depression leading to suicidal ideation in adolescents: a review.Cognitive neurodynamics · 2022Review
- Sleep disturbance and suicide risk among sexual and gender minority people.Neurobiology of stress · 2022Article
- Persistent Depressive Disorder-Related Effect of Sleep Disorder on the Highest Risk of Suicide in Taiwan, 2000-2015.International journal of environmental research and public health · 2022Article
- Verification of sleep scales as predictors of suicidal ideation in Japanese dayworkers: a longitudinal study.Sleep and biological rhythms · 2022Article
- Does Insomnia Increase the Risk of Suicide in Hospitalized Patients with Major Depressive Disorder? A Nationwide Inpatient Analysis from 2006 to 2015.Behavioral sciences (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDisturbed sleep may confer risk for suicidal behaviors. Polysomnographic (PSG) sleep parameters have not been systematically evaluated in association with suicidal ideation (SI) among individuals with treatment-resistant depression (TRD).
methodsThis secondary data analysis included 54 TRD individuals (N=30 with major depressive disorder (MDD) and N=24 with bipolar depression (BD)). PSG sleep parameters included Sleep Efficiency (SE), Total Sleep Time (TST), Wakefulness After Sleep Onset (WASO), REM percent/latency, and non-REM (NREM) Sleep Stages 1-4. The Hamilton Depression Rating Scale (HAM-D) was used to group participants according to presence or absence of SI. Sleep abnormalities were hypothesized among those with current SI. ANOVA analyses were conducted before (Model 1) and after adjusting for depression (Model 2) and diagnostic variables (Model 3).
resultsSignificant differences in PSG parameters were observed in Model 1; those with SI had less NREM Stage 4 sleep (p<.05). After adjusting for central covariates, Models 2 and 3 revealed significantly less NREM Stage 4 sleep, lower SE (P<.05), and higher WASO (P<.05) among those with SI. BD participants with SI also had less NREM Stage 4 and more NREM Stage 1 sleep. LIMITATIONS: 1) a predominantly white sample; 2) exclusion of imminent suicide risk; 3) concomitant mood stabilizer use among BD patients; and 4) single-item SI assessment.
conclusionsIndependent of depression severity, SI was associated with less NREM Stage 4 sleep, and higher nocturnal wakefulness across diagnostic groups. Sleep may warrant further investigation in the pathogenesis of suicide risk, particularly in TRD, where risk may be heightened.
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