Evidence map›Paper›PMID 27810700›Full record

ArticleBreast (Edinburgh, Scotland)2017

Robotic nipple-sparing mastectomy for the treatment of breast cancer: Feasibility and safety study.

Antonio Toesca, Nickolas Peradze, Andrea Manconi, Viviana Galimberti, Mattia Intra, Marco Colleoni, Bernardo Bonanni, Giuseppe Curigliano, Mario Rietjens, Giuseppe Viale and 2 more

8 registry-linked trialsOpen access · hybridAbstract readEvaluation Study
In one paragraph

Article in Breast (Edinburgh, Scotland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 82 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 6 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03440398 nacompletednot on this map

Robotic Nipple-Sparing Mastectomy And Immediate Robotic Breast Reconstruction Vs Conventional Open Technique: A Prospective Randomized Trial Evaluating Patients Satisfaction

TypeinterventionalSponsorEuropean Institute of OncologyRan2017 to 2026Enrolled82ConditionsBreast CancerArmsRobotic NSM, Open NSM
NCT03838549 nacompletednot on this mapstarted 2019, after this paper: background citation

Pre Pectoral Implant for Immediate Breast Reconstruction Using Single Port Endoscopy in Prophylactic Indication

TypeinterventionalSponsorUniversity Hospital, MontpellierRan2019 to 2025Enrolled20ConditionsGenetic Predisposition, Breast CancerArmsProphylactic mastectomy with immediate breast reconstruction
NCT04037852 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Robotic Versus Conventional or Endoscopic Nipple Sparing Mastectomy in the Management of Breast Cancer- A Prospective Registry Case Control Study

TypeinterventionalSponsorChanghua Christian HospitalRan2019 to 2022Enrolled180ConditionsBreast Cancer FemaleArmsrobotic assisted nipple sparing mastectomy, Endoscopic assisted nipple sparing mastectomy, Conventional nipple sparing mastectomy
NCT04049305 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Robotic Versus Conventional or Endoscopic Nipple Sparing Mastectomy in the Management of Breast Cancer- A Retrospective Study With Multi-center Pooled Data Analysis

TypeinterventionalSponsorChanghua Christian HospitalRan2019 to 2021Enrolled900ConditionsBreast Cancer FemaleArmsRobotic assisted nipple sparing mastectomy (R-NSM), conventional nipple sparing mastectomy (C-NSM), Endoscopic assisted nipple sparing mastectomy (E-NSM)
NCT04108117 completednot on this mapstarted 2020, after this paper: background citation

Surgical and Oncologic Outcomes After Robotic Nipple Sparing Mastectomy and Immediate Reconstruction : an International Multicenter Pooled Analysis

TypeobservationalSponsorSeverance HospitalRan2020 to 2022Enrolled659ConditionsPostoperative Complications, Recurrence, Breast Neoplasms, Breast CancerArmsRobotic nipple sparing mastectomy
NCT04151368 nasuspendednot on this mapstarted 2019, after this paper: background citation

Robotic Nipple-Sparing Mastectomy With Immediate Prosthetic Breast Reconstruction: Prospective Study of Feasibility, Safety and Patient Satisfaction, Toronto Experience.

TypeinterventionalSponsorUniversity Health Network, TorontoRan2019 to 2025Enrolled30ConditionsBreast Cancer, Surgery--Complications, Genetic Predisposition to Disease, SurgeryArmsRobotic Nipple-Sparing Mastectomy (RNSM)
NCT05448963 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Pilot Study of Robot-assisted Nipple-sparing Mastectomy Followed by Immediate Breast Reconstruction Using da Vinci SP ® Single-port System

TypeinterventionalSponsorChang Gung Memorial HospitalRan2022 to 2023Enrolled30ConditionsNipple-sparing Mastectomy, Prophylactic Mastectomy, Breast Cancer, BRCA1 MutationArmsda Vinci SPⓇ Single-port System
NCT07292246 narecruitingnot on this mapstarted 2025, after this paper: background citation

A Prospective CohorT Study of HandX - Assisted ENdoscopic MAstectomy: Feasibility and Safety (ATHENA I Study)

TypeinterventionalSponsorVasileios KallesRan2025 to 2029Enrolled15ConditionsBreast Cancer, BRCA 1 Gene Mutation, BRCA 2 Gene Mutation, Hereditary Breast CarcinomaArmsEndoscopic nipple sparing mastectomy, HandX endoscopic instrument
3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 6 syntheses or guidelines pooled it, 174 citations in OpenAlex.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Antonio ToescaDivision of Breast Surgery, European Institute of Oncology, Milan, Italy. Electronic address: antonio.toesca@ieo.it.
Nickolas PeradzeDivision of Breast Surgery, European Institute of Oncology, Milan, Italy.
Andrea ManconiDivision of Plastic and Reconstructive Surgery, European Institute of Oncology, Milan, Italy.
Viviana GalimbertiDivision of Breast Surgery, European Institute of Oncology, Milan, Italy.
Mattia IntraDivision of Breast Surgery, European Institute of Oncology, Milan, Italy.
Marco ColleoniDivision of Medical Senology, European Institute of Oncology, Milan, Italy.
Bernardo BonanniDivision of Cancer Prevention and Genetics, European Institute of Oncology, Milan, Italy.
Giuseppe CuriglianoEarly Drug Development for Innovative Therapies Division, European Institute of Oncology, Milan, Italy.
Mario RietjensDivision of Plastic and Reconstructive Surgery, European Institute of Oncology, Milan, Italy.
Giuseppe VialeDivision of Pathology, European Institute of Oncology, Milan, Italy; University of Milan, School of Medicine, Milan, Italy.
Virgilio SacchiniDivision of Breast Surgery, European Institute of Oncology, Milan, Italy; University of Milan, School of Medicine, Milan, Italy.
Paolo VeronesiDivision of Breast Surgery, European Institute of Oncology, Milan, Italy; University of Milan, School of Medicine, Milan, Italy.
European Institute of Oncology · ITUniversity of Milan · IT

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundWe previously devised and reported on an innovative surgical technique of robotic nipple-sparing mastectomy and immediate robotic breast reconstruction. Here we describe the outcome of the first 29 such consecutive procedures performed on breast cancer patients to assess feasibility, reproducibility and safety.

methodsThe following morbidity factors were tested: operation time, conversion rate to open technique, length of hospitalization, registration of complications for 1 year postoperatively and their characterization as either minor, major, or multiple, depending on clinical severity and treatment required.

resultsThe total duration of the final robotic surgeries of our series was around 3 h, showing a very rapid learning curve. The conversion rate due to technical problems was 2 of the 29 procedures (6,9%). No major complications, including hematoma, seroma, skin or nipple-areola injury or necrosis or infection were observed for any case. Two patients had a small degree of blistering from internal electrocautery in the breast skin flap, both of which resolved in one week without any specific therapy. No systemic complications were observed.

conclusionThe low conversion rate to open surgery, the rapid learning curve and the low rate of post-operative complications observed in this preliminary series lead us to endorse a prospective study aimed at evaluating patient satisfaction.

Indexed as

AdultBreast NeoplasmsConversion to Open SurgeryFeasibility StudiesFemaleHumansLength of StayMammaplastyMastectomy, SegmentalMiddle AgedNipplesOperative TimeOrgan Sparing TreatmentsPatient SatisfactionPostoperative ComplicationsProspective StudiesBreast cancerBreast reconstructionConservative mastectomyNipple-sparing mastectomyRisk-reducing surgeryRobotic mastectomy

Identifiers

PMID27810700
PMCPMC5278881
OpenAlexW2546879232

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 2 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.