Evidence map›Paper›PMID 27810563›Full record

ReviewMicrobes and infection2017

Impact of HIF-1α and hypoxia on fungal growth characteristics and fungal immunity.

Dirk Friedrich, Roger A Fecher, Jan Rupp, George S Deepe

Abstract readReview
In one paragraph

Review in Microbes and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. HIF-1alpha and infectious diseases: a new frontier for the development of new therapies.Revista do Instituto de Medicina Tropical de Sao Paulo · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Dirk FriedrichDepartment of Infectious Diseases and Microbiology, University of Lübeck, 23538 Lübeck, Germany. Electronic address: dirk.friedrich@uksh.de.
Roger A FecherDivision of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Immunobiology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45220, USA.
Jan RuppDepartment of Infectious Diseases and Microbiology, University of Lübeck, 23538 Lübeck, Germany.
George S DeepeDivision of Infectious Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Medical Service, Veterans Affairs Hospital, Cincinnati, OH 45220, USA.
University of Lübeck · DECincinnati Children's Hospital Medical Center · USVeterans Health Administration · US

Funding

HIF Regulation of Histoplasma PathogenesisR01AI133797 · NIAID · UNIVERSITY OF CINCINNATI · PI DEEPE, GEORGE S. · 2018 to 2022
$2.0M
NIAID NIH HHS R01 AI133797
6 · The paper itself

Abstract

Human pathogenic fungi are highly adaptable to a changing environment. The ability to adjust to low oxygen conditions is crucial for colonization and infection of the host. Recently, the impact of mammalian hypoxia-inducible factor-1α (HIF-1α) on fungal immunity has emerged. In this review, the role of hypoxia and HIF-1α in fungal infections is discussed regarding the innate immune response.

Indexed as

Immunity, InnateAnimalsDisease Models, AnimalFungiHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitMycosesHypoxia-Inducible Factor 1, alpha SubunitFungal immunityHIF-1HypoxiaSREBP

Identifiers

PMID27810563
PMCPMC6863052
OpenAlexW2544042958

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.