Evidence map›Paper›PMID 27810258›Full record

ArticleSleep medicine2016

Obstructive sleep apnea and incident type 2 diabetes.

Mako Nagayoshi, Naresh M Punjabi, Elizabeth Selvin, James S Pankow, Eyal Shahar, Hiroyasu Iso, Aaron R Folsom, Pamela L Lutsey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 6 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 6 syntheses or guidelines pooled it, 155 citations in OpenAlex.

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  8. The association between sleep-disordered breathing and maternal endothelial and metabolic markers in pregnancies complicated by obesity.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Mako NagayoshiDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA; Department of Community Medicine, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan. Electronic address: mnagayoshi@nagasaki-u.ac.jp.
Naresh M PunjabiDivision of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Elizabeth SelvinDepartment of Epidemiology and the Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Eyal ShaharDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Hiroyasu IsoDivision of Preventive and Environmental Medicine, Osaka University, Osaka, Japan.
Aaron R FolsomDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
Pamela L LutseyDivision of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USJohns Hopkins University · USNagasaki University · JPOsaka University · JPUniversity of Arizona · US

Funding

Diabetes and Prediabetes in Older Adults in ARICR01DK089174 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2011 to 2020
$6.4M
DATA COORDINATING CENTER FOR SLEEP HEART STUDYU01HL064360 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI DIENER-WEST, MARIE · 1999 to 2007
$4.4M
The Effects of Sleep Apnea on Metabolic FunctionR01HL075078 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PUNJABI, NARESH M · 2003 to 2013
$3.3M
Sleep Apnea and Longitudinal Changes in Glycemia and Inflammation in Older MenR01HL089467 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PUNJABI, NARESH M · 2008 to 2011
$1.6M
Longtitudinal Changes in Sleep Structure: Implications for Health OutcomesR01HL086862 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI PUNJABI, NARESH M · 2007 to 2010
$1.5M
THE SLEEP HEART HEALTH STUDYU01HL053934 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHAHAR, EYAL · 1994 to 2007
$1.4M
Research and Mentoring in the Clinical Epidemiology of Type 2 DiabetesK24DK106414 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SELVIN, ELIZABETH · 2015 to 2019
$654k
Sleep Disordered Breathing and Incident Cognitive Decline and Dementia: ARICR21HL121412 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2013 to 2014
$220k
NHLBI NIH HHS HHSN268201100005CNHLBI NIH HHS HHSN268201100005GNHLBI NIH HHS HHSN268201100005INHLBI NIH HHS HHSN268201100006CNHLBI NIH HHS HHSN268201100007CNHLBI NIH HHS HHSN268201100007INHLBI NIH HHS HHSN268201100008CNHLBI NIH HHS HHSN268201100008INHLBI NIH HHS HHSN268201100009CNHLBI NIH HHS HHSN268201100009INHLBI NIH HHS HHSN268201100010CNHLBI NIH HHS HHSN268201100011CNHLBI NIH HHS HHSN268201100011INHLBI NIH HHS HHSN268201100012CNHLBI NIH HHS R01 HL075078NHLBI NIH HHS R01 HL086862NHLBI NIH HHS R01 HL089467NHLBI NIH HHS R21 HL121412NHLBI NIH HHS U01 HL053934NHLBI NIH HHS U01 HL064360NIDDK NIH HHS K24 DK106414NIDDK NIH HHS R01 DK089174
6 · The paper itself

Abstract

objectivesTo determine whether severity of obstructive sleep apnea is associated with incident diabetes in middle-aged and older adults.

methodsA prospective analysis of 1453 non-diabetic participants of both the Atherosclerosis Risk in Communities Study and the Sleep Heart Health Study (mean age 63 years, 46% male) had in-home polysomnography (1996-1998) and was followed up for incident diabetes. Using the apnea-hypopnea index derived from home polysomnography, study participants were categorized as follows: <5.0 (normal), 5.0-14.9 (mild), 15.0-29.9 (moderate), and ≥30.0 events/h (severe). Incident diabetes was ascertained during annual follow-up telephone calls through 2013.

resultsDuring a median follow-up of 13 years, there were 285 incident diabetes cases among the 1453 participants. Participants with severe obstructive sleep apnea were at greater risk of incident diabetes compared to persons classified as normal after adjustment for confounders including body mass index and waist circumference (1.71 [1.08, 2.71]). The association between severe obstructive sleep apnea and incident diabetes was similar when analyses were restricted to obese individuals.

conclusionsSevere obstructive sleep apnea was associated with greater risk of incident diabetes, independent of adiposity in a community-based sample. Healthcare professionals should be cognizant of the high prevalence of OSA in the general population and the potential link to incident diabetes.

Indexed as

Body Mass IndexDiabetes Mellitus, Type 2FemaleHumansIncidenceMaleMiddle AgedObesityPolysomnographyProspective StudiesRisk FactorsSeverity of Illness IndexSleep Apnea, ObstructiveUnited StatesWaist CircumferenceDiabetesEpidemiologyObesityObstructive sleep apnea

Identifiers

PMID27810258
PMCPMC5102826
OpenAlexW2526646214

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.