ArticleClinical oncology (Royal College of Radiologists (Great Britain))2017
Initial Results from the Royal College of Radiologists' UK National Audit of Anal Cancer Radiotherapy 2015.
Article in Clinical oncology (Royal College of Radiologists (Great Britain)), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Optimising chemoradiotherapy in anal cancer.ESMO gastrointestinal oncology · 2026Review
- Inguinal CTV contouring in anal cancer: comparative validation of inguinal lymph nodes contouring guidelines and implications for consensus.Clinical and translational radiation oncology · 2026Article
- Clinical Outcomes, Patterns of Failure, and Salvage Therapies of a Large Modern Cohort of Patients With Anal Squamous Cell Carcinoma Treated With Definitive-Intent Intensity-Modulated Radiation Therapy.International journal of radiation oncology, biology, physics · 2025Article
- Study of long-term effects of pelvic radiotherapy on the function of bone marrow in recurrent cervical cancer patients.International journal of medical sciences · 2024Article
- Volumetric modulated arc therapy (VMAT): a review of clinical outcomes-what is the clinical evidence for the most effective implementation?The British journal of radiology · 2022Review
- Is cancer a prognostic factor for severe COVID-19, especially for breast cancer patients?Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique · 2022Review
- Quality of life in patients treated with radiochemotherapy for primary diagnosis of anal cancer.Scientific reports · 2022Article
- Intensity-modulated Radiotherapy for Rectal Cancer in the UK in 2020.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2021Article
- Improved treatment outcome and lower skin toxicity with intensity-modulated radiotherapy vs. 3D conventional radiotherapy in anal cancer.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2020Article
- Patterns and Predictors of Relapse Following Radical Chemoradiation Therapy Delivered Using Intensity Modulated Radiation Therapy With a Simultaneous Integrated Boost in Anal Squamous Cell Carcinoma.International journal of radiation oncology, biology, physics · 2020Article
- Response of FDG avid pelvic bone marrow to concurrent chemoradiation for anal cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2020Observational
- Target volume motion during anal cancer image guided radiotherapy using cone-beam computed tomography.The British journal of radiology · 2018Article
- Management of early anal cancer: need for guidelines and standardisation.International journal of colorectal disease · 2017Article
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Authors and funding
9 authors at 7 institutions in 1 country.
Funding
Abstract
aimsUK guidance was recently developed for the treatment of anal cancer using intensity-modulated radiotherapy (IMRT). We audited the current use of radiotherapy in UK cancer centres for the treatment of anal cancer against such guidance. We describe the acute toxicity of IMRT in comparison with patient population in the audit treated with two-phase conformal radiotherapy and the previous published data from two-phase conformal radiotherapy, in the UK ACT2 trial. MATERIALS AND
methodsA Royal College of Radiologists' prospective national audit of patients treated with radiotherapy in UK cancer centres was carried out over a 6 month period between February and July 2015.
resultsTwo hundred and forty-two cases were received from 40/56 cancer centres (71%). In total, 231 (95%) underwent full dose radiotherapy with prophylactic nodal irradiation. Of these, 180 (78%) received IMRT or equivalent, 52 (22%) two-phase conformal (ACT2) technique. The number of interruptions in radiotherapy treatment in the ACT2 trial was 15%. Interruptions were noted in 7% (95% confidence interval 0-14%) of courses receiving two-phase conformal and 4% (95% confidence interval 1-7%) of those receiving IMRT. The percentage of patients completing the planned radiotherapy dose, irrelevant of gaps, was 90% (95% confidence interval 82-98%) and 96% (95% confidence interval 93-99%), in two-phase conformal and IMRT respectively. The toxicity reported in the ACT2 trial, in patients receiving two-phase conformal in the audit and in patients receiving IMRT in the audit was: any toxic effect 71%, 54%, 48%, non-haematological 62%, 49%, 40% and haematological 26%, 13%, 18%, respectively.
conclusionsIMRT implementation for anal cancer is well underway in the UK with most patients receiving IMRT delivery, although its usage is not yet universal. This audit confirms that IMRT results in reduced acute toxicity and minimised treatment interruptions in comparison with previous two-phase conformal techniques.
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