Trial reportHealth and quality of life outcomes2016
Quality of life and related factors among chronic hepatitis B-infected patients: a multi-center study, Turkey.
Abstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Health and quality of life outcomes, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Health-related quality of life improves after entecavir treatment in patients with compensated HBV cirrhosis.Hepatology international · 2021Trial
- Health-related quality of life in adults with hepatitis B in sub-Saharan Africa: the added burden of HIV co-infection.BMC infectious diseases · 2026Observational
- Quantitatively Evaluate the Improvement of Functional Cure for the Quality of Life of Chronic Hepatitis B Cases: Evidence from a Cross-Sectional Study in China.Healthcare (Basel, Switzerland) · 2025Article
- HBV-Induced Carcinogenesis: Mechanisms, Correlation With Viral Suppression, and Implications for Treatment.Liver international : official journal of the International Association for the Study of the Liver · 2025Review
- Effect of interferon therapy on quality of life in patients with chronic hepatitis B.Scientific reports · 2024Article
- Symptoms of Liver Disease During Tenofovir Therapy With or Without Peginterferon: Results from the Hepatitis B Research Network Immune Active Trial.Digestive diseases and sciences · 2023Article
- Health-Related Quality of Life in Patients with Chronic Hepatitis B: A Meta-Analysis of Observational Studies.Iranian journal of public health · 2023Review
- The Impact of Living With Chronic Hepatitis B on Quality of Life: Implications for Clinical Management.Journal of patient experience · 2023Article
- The effect of a pay-for-performance program on health-related quality of life for patients with hepatitis in Taiwan.Health and quality of life outcomes · 2022Article
- Quality of life and unmet needs in patients with chronic liver disease: A mixed-method systematic review.JHEP reports : innovation in hepatology · 2021Article
- Article
- Mental and physical health status among chronic hepatitis B patients.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- The Lived Experience of Chronic Hepatitis B: A Broader View of Its Impacts and Why We Need a Cure.Viruses · 2020Review
- Patient-reported outcomes in a large North American cohort living with chronic hepatitis B virus: a cross-sectional analysis.Alimentary pharmacology & therapeutics · 2020Article
- The Impact of Virologic Parameters and Liver Fibrosis on Health-Related Quality of Life in Black African Patients with Chronic Hepatitis B: Results from a High Endemic Area.Clinical and experimental gastroenterology · 2020Article
- Prevalence of Transfusion Transmitted Infections and the Quality of Life in β-thalassemia Major Patients.Cureus · 2019Article
- Article
- Deficiency, incapacity and social disadvantage of patients with chronic hepatitis B: a case-control study.La Tunisie medicaleArticle
Corrections and comments
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Authors and funding
78 authors.
Zehra KaracaerDepartment of Infectious Diseases and Clinical Microbiology, Etimesgut Military Hospital, Ankara, Turkey. zehrakaracaer@yahoo.com.ORCID http://orcid.org/0000-0002-2658-4679
Banu CakirInstitute of Public Health, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Hakan ErdemDepartment of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy, Ankara, Turkey.
Kenan UgurluDepartment of Infectious Diseases and Clinical Microbiology, 25 Aralık State Hospital, Gaziantep, Turkey.
Gul DurmusDepartment of Infectious Diseases and Clinical Microbiology, Sevket Yilmaz Training and Research Hospital, Bursa, Turkey.
Nevin Koc InceDepartment of Infectious Diseases and Clinical Microbiology, Duzce University School of Medicine, Duzce, Turkey.
Cinar OzturkDepartment of Infectious Diseases and Clinical Microbiology, Recep Tayyip Erdogan University School of Medicine, Rize, Turkey.
Rodrigo HasbunDepartment of Infectious Diseases, The University of Texas Health Science Center at Houston, Medical School, Houston, TX, USA.
Ayse BatirelDepartment of Infectious Diseases and Clinical Microbiology, Kartal Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey.
Esmeray Mutlu YilmazDepartment of Infectious Diseases and Clinical Microbiology, Samsun Training and Research Hospital, Samsun, Turkey.
Ilkay BozkurtDepartment of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
Mustafa SunbulDepartment of Infectious Diseases and Clinical Microbiology, Ondokuz Mayis University School of Medicine, Samsun, Turkey.
Aynur AyniogluDepartment of Infectious Diseases and Clinical Microbiology, Ataturk State Hospital, Zonguldak, Turkey.
Aynur AtillaDepartment of Infectious Diseases and Clinical Microbiology, Samsun Training and Research Hospital, Samsun, Turkey.
Ayse ErbayDepartment of Infectious Diseases and Clinical Microbiology, Bozok University School of Medicine, Yozgat, Turkey.
Ayse InciDepartment of Infectious Diseases and Clinical Microbiology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
Cigdem KaderDepartment of Infectious Diseases and Clinical Microbiology, Bozok University School of Medicine, Yozgat, Turkey.
Elif Tukenmez TigenDepartment of Infectious Diseases and Clinical Microbiology, Marmara University Pendik Training and Research Hospital, Istanbul, Turkey.
Gokhan KaraahmetogluDepartment of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy Haydarpasa Training and Research Hospital, Istanbul, Turkey.
Seher Ayten CoskunerDepartment of Infectious Diseases and Clinical Microbiology, Bozyaka Training and Research Hospital, Izmir, Turkey.
Ebru DikDepartment of Infectious Diseases and Clinical Microbiology, Bozyaka Training and Research Hospital, Izmir, Turkey.
Huseyin TarakciDepartment of Infectious Diseases and Clinical Microbiology, Izmir Metropolitan Municipalities Esrefpasa Hospital, Izmir, Turkey.
Selma TosunDepartment of Infectious Diseases and Clinical Microbiology, Bozyaka Training and Research Hospital, Izmir, Turkey.
Fatime KorkmazDepartment of Infectious Diseases and Clinical Microbiology, Konya Training and Research Hospital, Konya, Turkey.
Servet KolgelierDepartment of Infectious Diseases and Clinical Microbiology, Yildirim Beyazit University Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Fatma Yilmaz KaradagDepartment of Infectious Diseases and Clinical Microbiology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.
Serpil ErolDepartment of Infectious Diseases and Clinical Microbiology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
Kamuran TurkerDepartment of Infectious Diseases and Clinical Microbiology, Bagcilar Training and Research Hospital, Istanbul, Turkey.
Ceyda NecanDepartment of Infectious Diseases and Clinical Microbiology, Pamukkale University School of Medicine, Denizli, Turkey.
Ahmet Melih SahinDepartment of Infectious Diseases and Clinical Microbiology, Giresun State Hospital, Giresun, Turkey.
Pinar ErgenDepartment of Infectious Diseases and Clinical Microbiology, Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.
Gulsen IskenderDepartment of Infectious Diseases and Clinical Microbiology, Ankara Oncology Training and Research Hospital, Ankara, Turkey.
Pinar KorkmazDepartment of Infectious Diseases and Clinical Microbiology, Dumlupinar University Evliya Celebi Training and Research Hospital, Kutahya, Turkey.
Esma Gulesen ErogluDepartment of Infectious Diseases and Clinical Microbiology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey.
Yasemin DurduDepartment of Infectious Diseases and Clinical Microbiology, Eyup State Hospital, Istanbul, Turkey.
Mehmet UlugDepartment of Infectious Diseases and Clinical Microbiology, Umit Hospital, Eskisehir, Turkey.
Suna Secil DenizDepartment of Infectious Diseases and Clinical Microbiology, Kecioren Training and Research Hospital, Ankara, Turkey.
Filiz KocDepartment of Infectious Diseases and Clinical Microbiology, Kecioren Training and Research Hospital, Ankara, Turkey.
Saygın Nayman AlpatDepartment of Infectious Diseases and Clinical Microbiology, Osmangazi University School of Medicine, Eskisehir, Turkey.
Nefise OztoprakDepartment of Infectious Diseases and Clinical Microbiology, Antalya Training and Research Hospital, Antalya, Turkey.
Omer EvirgenDepartment of Infectious Diseases and Clinical Microbiology, Mustafa Kemal University School of Medicine, Hatay, Turkey.
Hamdi SozenDepartment of Infectious Diseases and Clinical Microbiology, Sitki Kocman University School of Medicine, Mugla, Turkey.
Mustafa DoganDepartment of Infectious Diseases and Clinical Microbiology, Corlu State Hospital, Tekirdag, Turkey.
Selcuk KayaDepartment of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey.
Safak KayaDepartment of Infectious Diseases and Clinical Microbiology, Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey.
Mustafa AltindisDepartment of Clinical Microbiology, Sakarya University School of Medicine, Sakarya, Turkey.
Emel AslanDepartment of Infectious Diseases and Clinical Microbiology, Dicle University School of Medicine, Diyarbakir, Turkey.
Recep TekinDepartment of Infectious Diseases and Clinical Microbiology, Dicle University School of Medicine, Diyarbakir, Turkey.
Busra Ergut SezerDepartment of Infectious Diseases and Clinical Microbiology, Corlu State Hospital, Tekirdag, Turkey.
Kevser OzdemirDepartment of Infectious Diseases and Clinical Microbiology, Denizli State Hospital, Denizli, Turkey.
Gulden ErsozDepartment of Infectious Diseases and Clinical Microbiology, Mersin University School of Medicine, Mersin, Turkey.
Ahmet SahinDepartment of Infectious Diseases and Clinical Microbiology, Gaziantep University School of Medicine, Gaziantep, Turkey.
Ilhami CelikDepartment of Infectious Diseases and Clinical Microbiology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Emsal AydinDepartment of Infectious Diseases and Clinical Microbiology, Kafkas University School of Medicine, Kars, Turkey.
Aliye BastugDepartment of Infectious Diseases and Clinical Microbiology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Rezan HarmanDepartment of Infectious Diseases and Clinical Microbiology, Sani Konukoglu Hospital, Gaziantep, Turkey.
Hacer Deniz OzkayaDepartment of Infectious Diseases and Clinical Microbiology, Karsıkaya State Hospital, Izmir, Turkey.
Emine ParlakDepartment of Infectious Diseases and Clinical Microbiology, Ataturk University School of Medicine, Erzurum, Turkey.
Ilknur YavuzDepartment of Infectious Diseases and Clinical Microbiology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkey.
Suzan SacarDepartment of Infectious Diseases and Clinical Microbiology, Onsekiz Mart University School of Medicine, Canakkale, Turkey.
Senol ComogluDepartment of Infectious Diseases and Clinical Microbiology, Umraniye Training and Research Hospital, Istanbul, Turkey.
Ercan YenilmezDepartment of Infectious Diseases and Clinical Microbiology, Kasimpasa Military Hospital, Istanbul, Turkey.
Fatma SirmatelDepartment of Infectious Diseases and Clinical Microbiology, Abant Izzet Baysal University School of Medicine, Bolu, Turkey.
Ilker Inanc BalkanDepartment of Infectious Diseases and Clinical Microbiology, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey.
Yesim AlpayDepartment of Infectious Diseases and Clinical Microbiology, Balikesir University School of Medicine, Balikesir, Turkey.
Mustafa HatipogluDepartment of Infectious Diseases and Clinical Microbiology, Canakkale Military Hospital, Canakkale, Turkey.
Affan DenkDepartment of Infectious Diseases and Clinical Microbiology, Firat University School of Medicine, Elazig, Turkey.
Gunes SenolDepartment of Infectious Diseases and Clinical Microbiology, Izmir Dr. Suat Seren Pulmonology and Pulmonary Surgery Training and Research Hospital, Izmir, Turkey.
Mehmet BitirgenDepartment of Infectious Diseases and Clinical Microbiology, Necmettin Erbakan University, Meram School of Medicine, Konya, Turkey.
Mehmet Faruk GeyikDepartment of Infectious Diseases and Clinical Microbiology, Duzce University School of Medicine, Duzce, Turkey.
Rahmet GunerDepartment of Infectious Diseases and Clinical Microbiology, Yildirim Beyazit University Ankara Ataturk Training and Research Hospital, Ankara, Turkey.
Ayten KadanaliDepartment of Infectious Diseases and Clinical Microbiology, Umraniye Training and Research Hospital, Istanbul, Turkey.
Ahmet KarakasDepartment of Infectious Diseases and Clinical Microbiology, Gulhane Military Medical Academy, Ankara, Turkey.
Mustafa NamiduruDepartment of Infectious Diseases and Clinical Microbiology, Gaziantep University School of Medicine, Gaziantep, Turkey.
Hatice UdurgucuDepartment of Infectious Diseases and Clinical Microbiology, Firat University School of Medicine, Elazig, Turkey.
Rukiye Pinar BoluktasFaculty of Health Sciences, Department of Nursing, Selahaddin Eyyubi University, Diyarbakir, Turkey.
Ergenekon KaragozDepartment of Infectious Diseases and Clinical Microbiology, Van Military Hospital, Van, Turkey.
Necati OrmeciDepartment of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors.
methodsThis multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant.
resultsFour thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided.
conclusionsThe HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.
Indexed as
Hepatitis B, ChronicQuality of LifeAdultAgedAntiviral AgentsCross-Sectional StudiesFemaleHealth Status IndicatorsHumansInterviews as TopicMaleMiddle AgedProspective StudiesTurkeyAntiviral AgentsChronic hepatitis B infectionQuality of lifeThe Hepatitis B Quality of Life InstrumentTurkey
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