Evidence map›Paper›PMID 27809917›Full record

ArticleEnvironmental health : a global access science source2016

Gene expression network analyses in response to air pollution exposures in the trucking industry.

Jen-Hwa Chu, Jaime E Hart, Divya Chhabra, Eric Garshick, Benjamin A Raby, Francine Laden

Open access · goldAbstract read
In one paragraph

Article in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Cardiovascular adaptations to particle inhalation exposure: molecular mechanisms of the toxicology.American journal of physiology. Heart and circulatory physiology · 2020
    Review
  10. Article
  11. Metabolomic assessment of exposure to near-highway ultrafine particles.Journal of exposure science & environmental epidemiology · 2019
    Article
  12. Ambient Pollution-related Reprogramming of the Human Small Airway Epithelial Transcriptome.American journal of respiratory and critical care medicine · 2018
    Article
  13. Mechanisms and Measurement of Changes in Gene Expression.Biological research for nursing · 2018
    Article
  14. Article
  15. Prediction of microRNA and gene target from an integrated network in chronic obstructive pulmonary disease based on canonical correlation analysis.Technology and health care : official journal of the European Society for Engineering and Medicine · 2018
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jen-Hwa ChuSection of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA. jen-hwa.chu@yale.edu.ORCID 0000-0001-7179-9428
Jaime E HartChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Divya ChhabraChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Eric GarshickChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Benjamin A RabyChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Francine LadenChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Brigham and Women's Hospital · USYale University · US

Funding

BIOMARKERS OF EXPOSURE AND EFFECT IN A TRAFFIC EXPOSED POPULATIONR01ES016284 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI LADEN, FRANCINE · 2008 to 2011
$2.8M
Causal Inference of Disease-Relevant Regulatory NetworksR00HL114651 · NHLBI · YALE UNIVERSITY · PI CHU, JEN-HWA · 2016 to 2018
$741k
Causal Inference of Disease-Relevant Regulatory NetworksK99HL114651 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHU, JEN-HWA · 2013 to 2014
$274k
NHLBI NIH HHS K99 HL114651NHLBI NIH HHS R00 HL114651NIEHS NIH HHS R01 ES016284
6 · The paper itself

Abstract

backgroundExposure to air pollution, including traffic-related pollutants, has been associated with a variety of adverse health outcomes, including increased cardiopulmonary morbidity and mortality, and increased lung cancer risk.

methodsTo better understand the cellular responses induced by air pollution exposures, we performed genome-wide gene expression microarray analysis using whole blood RNA sampled at three time-points across the work weeks of 63 non-smoking employees at 10 trucking terminals in the northeastern US. We defined genes and gene networks that were differentially activated in response to PM

resultsMultiple transcripts were strongly associated (p

conclusionsThese data provide a molecular link between the associations of air pollution exposures with health effects.

Indexed as

Gene Expression ProfilingMotor VehiclesAdultAir PollutantsAir PollutionCarbonEnvironmental ExposureHumansMaleMicroarray AnalysisMiddle AgedParticulate MatterAir PollutantsCarbonParticulate MatterAir pollutionGene expressionNetwork analysisTrucking industry

Identifiers

PMID27809917
PMCPMC5093980
OpenAlexW2548599179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.