ArticleBMC pulmonary medicine2016
Hospitalizations due to respiratory failure in patients with Amyotrophic Lateral Sclerosis and their impact on survival: a population-based cohort study.
Article in BMC pulmonary medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Immunosuppression in stem cell clinical trials of neural and retinal cell types: A systematic review.PloS one · 2024Pooled it
- Possible Paraneoplastic Amyotrophic Lateral Sclerosis Presenting as Respiratory Failure in a Breast Cancer Patient: A Case Report.Clinical case reports · 2026Article
- Lung Volume Recruitment Slows Pulmonary Functional Decline and Prolongs Survival in ALS.Journal of neurologic physical therapy : JNPT · 2026Article
- Emergency department visits among patients with neuromuscular diseases receiving home mechanical ventilation: a nationwide population-based study.Journal of Yeungnam medical science · 2026Article
- Noninvasive Ventilation Effectiveness in Amyotrophic Lateral Sclerosis.Journal of clinical medicine · 2025Review
- Epidemiology, disease evolution and economic burden of amyotrophic lateral sclerosis in France using the French national health data system.Brain communications · 2025Article
- Safety assessment of Edaravone: A real-world adverse event analysis based on the FAERS Database.PloS one · 2025Article
- End-of-Life Health Care Service Use and Cost Among Medicare Decedents With Neurodegenerative Diseases.Neurology · 2024Article
- Venous thromboembolism risk in amyotrophic lateral sclerosis: a hospital record-linkage study.Journal of neurology, neurosurgery, and psychiatry · 2024Article
- Trends in Hospital Admissions for Patients with Amyotrophic Lateral Sclerosis: Insights from a Retrospective Cohort Study in a Province in Northern Italy.Life (Basel, Switzerland) · 2024Article
- Healthcare Utilization and Supportive Care Timing in South Korean People Living With Amyotrophic Lateral Sclerosis: A Single-Center Retrospective Study.Journal of clinical neurology (Seoul, Korea) · 2024Article
- Linking Oropharyngeal Swallowing Physiology and Functional Clinical Predictors in Amyotrophic Lateral Sclerosis.Perspectives of the ASHA special interest groups · 2024Article
- Factors associated with adherence to noninvasive positive pressure ventilation in amyotrophic lateral sclerosis.PloS one · 2024Article
- How to increase noninvasive ventilation effectiveness in bulbar amyotrophic lateral sclerosis patients.Breathe (Sheffield, England) · 2023Article
- Clinical Characteristics and Outcome of MDR/XDR Bacterial Infections in a Neuromuscular Semi-Intensive/Sub-Intensive Care Unit.Antibiotics (Basel, Switzerland) · 2022Article
- Intravenous edaravone treatment in ALS and survival: An exploratory, retrospective, administrative claims analysis.EClinicalMedicine · 2022Article
- Lung volume recruitment improves volitional airway clearance in amyotrophic lateral sclerosis.Muscle & nerve · 2021Article
- Unstable control of breathing can lead to ineffective noninvasive ventilation in amyotrophic lateral sclerosis.ERJ open research · 2019Article
- The burden of sialorrhoea in chronic neurological conditions: current treatment options and the role of incobotulinumtoxinA (Xeomin®).Therapeutic advances in neurological disorders · 2019Article
- Sialorrhea in patients with ALS: current treatment options.Degenerative neurological and neuromuscular disease · 2019Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory failure, infections and aspiration pneumonia, are the main causes of morbidity and mortality in Amyotrophic Lateral Sclerosis (ALS). In a population-based cohort, we assessed (a) hospital utilization and (b) impact of hospitalization for respiratory failure on survival.
methodsAll patients with incident ALS in Friuli Venezia Giulia region, Italy, from 2002 to 2009, were identified through multiple sources. Diagnosis was validated through clinical documentation review. For each patient, we extracted the records of all hospitalizations after ALS diagnosis from the regional hospitalization database. Cox proportional hazards model survival Hazard Ratio (HR), with 95 % Confidence Interval (95 % CI), was calculated.
resultsOut of 262 patients, 98.1 % had at least 1 and 58.0 % ≥3 hospitalizations. Emergency admissions occurred in 77.5 % of patients and a diagnosis of respiratory failure in 55.0 %. Patients underwent a total of 885 hospitalizations. The leading diagnosis was respiratory failure (31.6 % of hospitalizations). This diagnosis occurred most frequently in emergency (45.6 %) than in elective admissions (26.4 %). The second leading diagnosis was pneumonia (14.2 %), 24.9 and 6.3 % respectively. The leading procedure was mechanical ventilation (18.4 %), performed in 29.9 % of emergency and in 12.4 % of elective admissions. After adjustment for site of onset, age and diagnostic delay, a first hospitalization for respiratory failure had a strong adverse effect on survival (HR 4.00; 95 % CI 3.00; 5.34).
conclusionsRespiratory failure, pneumonia and aspiration pneumonia were major determinants of hospitalizations and emergency admissions and often dealt with in emergency admissions. A first hospitalization for respiratory failure had a strong adverse effect on survival. Strategies to improve home management of respiratory conditions in patients with ALS and to optimize hospital care utilization are needed.
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