ReviewBMC cardiovascular disorders2016
Hypertension and cognitive dysfunction in elderly: blood pressure management for this global burden.
Review in BMC cardiovascular disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 4 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Evaluation of Event-Related Potentials in Somatic Diseases - Systematic Review.Applied psychophysiology and biofeedback · 2024Pooled it
- Prevalence and risk factors of cognitive impairment in Chinese patients with hypertension: a systematic review and meta-analysis.Frontiers in neurology · 2023Pooled it
- The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019).Hypertension research : official journal of the Japanese Society of Hypertension · 2019Guideline
- Associations of anthropometric adiposity indexes with hypertension risk: A systematic review and meta-analysis including PURE-China.Medicine · 2018Pooled it
- Clinical modifiers of the association between type 1 diabetes and dementia incidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Transcranial Direct Current Stimulation Attenuates Ischemic Stroke-Induced Autonomic and Behavioral Dysfunction via a RAS-Autophagy-Iron Axis in the Brainstem.Journal of neurochemistry · 2026Article
- Combined Effect of Toothbrushing and Interdental Cleaning on the Risk of Dementia.Yonsei medical journal · 2026Article
- Associations of Dietary Decanoic Acid Intake With Cognitive Function in the Elderly and the Mediating Effects of Hypertension and Diabetes: An Analysis From NHANES 2011-2014.Brain and behavior · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Hypertensive dementia and blood pressure management from JSH2025.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Life-Course Burden of Blood Pressure Is Associated With Midlife Cognitive Function.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Fall risk and its associated factors among hypertensive older adults in Dhulikhel municipality, Nepal.Aging clinical and experimental research · 2025Article
- Impact of cardiometabolic conditions on the progression from mild cognitive impairment to dementia: A large cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The association between metabolic syndrome severity and frailty risk in patients with rheumatoid arthritis: a cross-sectional study.Arthritis research & therapy · 2025Article
- Article
- Risk Factors, Pathological Changes, and Potential Treatment of Diabetes-Associated Cognitive Dysfunction.Journal of diabetes · 2025Review
- Cognitive impairment in CKD patients: a guidance document by the CONNECT network.Clinical kidney journal · 2025Review
- Association Between Sugar-Sweetened Beverage Consumption and Frailty Among Older Adults With Hypertension: Evidence From the National Health and Nutrition Examination Survey 1999-2020.Food science & nutrition · 2025Article
- The Concurrent Association of Magnesium and Calcium Deficiencies with Cognitive Function in Older Hospitalized Adults.Nutrients · 2024Article
- High Blood Pressure-Associated Symptoms: Insights From a Population-Based Study in Pakistan.Cureus · 2024Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial hypertension and stroke are strong independent risk factors for the development of cognitive impairment and dementia. Persistently elevated blood pressure (BP) is known to impair cognitive function, however onset of new cognitive decline is common following a large and multiple mini strokes. Among various forms of dementia the most prevalent include Alzheimer's disease (AD) and vascular dementia (VaD) which often present with similar clinical symptoms and challenging diagnosis. While hypertension is the most important modifiable vascular risk factor with antihypertensive therapy reducing the risk of stroke and potentially slowing cognitive decline, optimal BP levels for maintaining an ideal age-related mental performance are yet to be established. Cognition has improved following the use of at least one representative agent of the major drug classes with further neuroprotection with renin angiotensin inhibitors and calcium channel blockers in the hypertensive elderly. However, a reduction in BP may worsen cerebral perfusion causing an increased risk of CV complications due to the J-curve phenomenon. Given the uncertainties and conflicting results from randomized trials regarding the hypertension management in the elderly, particularly octogenarians, antihypertensive approaches are primarily based on expert opinion. Herein, we summarize available data linking arterial hypertension to cognitive decline and antihypertensive approach with potential benefits in improving cognitive function in elderly hypertensive patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.