ArticleBMC genomics2016
Recombination events among virulence genes in malaria parasites are associated with G-quadruplex-forming DNA motifs.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Review
- Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum.International journal for parasitology. Drugs and drug resistance · 2023Article
- Antigenic diversity in malaria parasites is maintained on extrachromosomal DNA.bioRxiv : the preprint server for biology · 2023Article
- Article
- G-quadruplex RNA motifs influence gene expression in the malaria parasite Plasmodium falciparum.Nucleic acids research · 2021Article
- Crucial Role of the C-Terminal Domain of Hfq Protein in Genomic Instability.Microorganisms · 2020Article
- Exploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite.Molecular systems biology · 2020Article
- Genome wide distribution of G-quadruplexes and their impact on gene expression in malaria parasites.PLoS genetics · 2020Article
- Conserved associations between G-quadruplex-forming DNA motifs and virulence gene families in malaria parasites.BMC genomics · 2020Article
- Review
- Generation and functional characterisation of Plasmodium yoelii csp deletion mutants using a microhomology-based CRISPR/Cas9 method.International journal for parasitology · 2019Article
- G-quadruplexes may determine the landscape of recombination in HSV-1.BMC genomics · 2019Article
- Rapid antigen diversification through mitotic recombination in the human malaria parasite Plasmodium falciparum.PLoS biology · 2019Article
- Parasitic Protozoa: Unusual Roles for G-Quadruplexes in Early-Diverging Eukaryotes.Molecules (Basel, Switzerland) · 2019Review
- Complex DNA structures trigger copy number variation across the Plasmodium falciparum genome.Nucleic acids research · 2019Article
- G-Quadruplexes: More Than Just a Kink in Microbial Genomes.Trends in microbiology · 2019Review
- G-Quadruplex DNA and RNA.Methods in molecular biology (Clifton, N.J.) · 2019Article
- RecQ helicases in the malaria parasite Plasmodium falciparum affect genome stability, gene expression patterns and DNA replication dynamics.PLoS genetics · 2018Article
- G-Quadruplex DNA Motifs in the Malaria Parasite Plasmodium falciparum and Their Potential as Novel Antimalarial Drug Targets.Antimicrobial agents and chemotherapy · 2018Article
- G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents.Journal of medicinal chemistry · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMalaria parasites of the genus Plasmodium possess large hyper-variable families of antigen-encoding genes. These are often variantly-expressed and are major virulence factors for immune evasion and the maintenance of chronic infections. Recombination and diversification of these gene families occurs readily, and may be promoted by G-quadruplex (G4) DNA motifs within and close to the variant genes. G4s have been shown to cause replication fork stalling, DNA breakage and recombination in model systems, but these motifs remain largely unstudied in Plasmodium.
resultsWe examined the nature and distribution of putative G4-forming sequences in multiple Plasmodium genomes, finding that their co-distribution with variant gene families is conserved across different Plasmodium species that have different types of variant gene families. In P. falciparum, where a large set of recombination events that occurred over time in cultured parasites has been mapped, we found a strong spatial association between these recombination events and putative G4-forming sequences. Finally, we searched Plasmodium genomes for the three classes of helicase that can unwind G4s: Plasmodium spp. have no identifiable homologue of the highly efficient G4 helicase PIF1, but they do encode two putative RecQ helicases and one homologue of the RAD3-family helicase FANCJ.
conclusionsOur analyses, conducted at the whole-genome level in multiple species of Plasmodium, support the concept that G4s are likely to be involved in recombination and diversification of antigen-encoding gene families in this important protozoan pathogen.
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