Evidence map›Paper›PMID 27809773›Full record

Trial reportBMC cardiovascular disorders2016

Electrocardiographic and Echocardiographic predictors of paroxysmal atrial fibrillation detected after ischemic stroke.

Maria A Baturova, Seth H Sheldon, Jonas Carlson, Peter A Brady, Grace Lin, Alejandro A Rabinstein, Paul A Friedman, Pyotr G Platonov

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMC cardiovascular disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01325545 (Detection of Occult Paroxysmal Atrial Fibrillation in Patients With Cryptogenic Stroke or TIA Using 21-Day Mobile Cardiac Outpatient Telemetry), which is not on this map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01325545 completednot on this map

Detection of Occult Paroxysmal Atrial Fibrillation in Patients With Cryptogenic Stroke or TIA Using 21-Day Mobile Cardiac Outpatient Telemetry

TypeobservationalSponsorMayo ClinicRan2009 to 2011Enrolled132ConditionsStroke, Atrial FibrillationArmsMobile cardiac rhythm monitoring
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Atrial strain and occult atrial fibrillation in cryptogenic stroke patients: a systematic review and meta-analysis.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Pooled it
  2. Electrocardiographic Predictors of Atrial Fibrillation.Medical sciences (Basel, Switzerland) · 2023
    Pooled it
  3. Predictive value of P wave terminal force in lead V1 for atrial fibrillation: A meta-analysis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2020
    Pooled it
  4. Trial
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  12. Electrocardiographic predictors of early recurrence of atrial fibrillation.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2021
    Article
  13. Review
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  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Maria A BaturovaDepartment of Cardiology, Clinical Science, Lund University, Lund, SE-221 85, Sweden. Maria.Baturova@med.lu.se.
Seth H SheldonDepartment of Cardiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55902, USA.
Jonas CarlsonDepartment of Cardiology, Clinical Science, Lund University, Lund, SE-221 85, Sweden.
Peter A BradyDepartment of Cardiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55902, USA.
Grace LinDepartment of Cardiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55902, USA.
Alejandro A RabinsteinDepartment of Neurology, Mayo Clinic, Mayo West 8B, 200 First Street SW, Mayo Clinic, Rochester, Minnesota, 55905, USA.
Paul A FriedmanDepartment of Cardiology, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55902, USA.
Pyotr G PlatonovDepartment of Cardiology, Clinical Science, Lund University, Lund, SE-221 85, Sweden.
Mayo Clinic · USLund University · SESkåne University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDetection of atrial fibrillation after ischemic stroke is challenging due to its paroxysmal nature. We aimed to assess predictors of paroxysmal atrial fibrillation using non-invasive surface ECG and transthoracic echocardiography to select candidates for atrial fibrillation screening.

methodsIschemic stroke patients without documented atrial fibrillation (n = 110, 67 ± 10 years, 40 female) and a control group of age- and gender-matched patients with history of paroxysmal atrial fibrillation prior to stroke (n = 55, 67 ± 10 years, 19 female) comprised the study sample. Using non-invasive ECG monitoring for three weeks, short episodes of paroxysmal atrial fibrillation were detected in 24 of 110 patients (22 %). The standard 12-lead ECG with sinus rhythm at stroke onset was digitally processed and analyzed. Transthoracic echocardiography data were reviewed for these patients.

resultsAtrial fibrillation history was independently associated with P terminal force in lead V 1 > 40 mm*ms (OR 4.04 95 % CI 1.34-12.14, p = 0.013) and left atrial volume index (OR 1.08 95 % CI 1.03-1.13, p = 0.002; for LAVI > 40 mL/m

conclusionIn a post hoc analysis, left atrial dilatation assessed by left atrial volume index independently predicted atrial fibrillation after stroke in patients without prior atrial fibrillation history, while the other clinical or ECG markers were not predictive of atrial fibrillation detected early after ischemic stroke.

trial registrationThis study is a post hoc analysis from the prospective case-control study registered in December 2011, ClinicalTrials.gov ID: NCT01325545 .

Indexed as

AgedAtrial FibrillationBrain IschemiaEchocardiographyElectrocardiographyFemaleHumansMalePredictive Value of TestsProspective StudiesRisk FactorsROC CurveTachycardia, ParoxysmalTime FactorsAtrial fibrillationECGIschemic strokeLeft atrial volume index

Identifiers

PMID27809773
PMCPMC5093933
OpenAlexW2547462662

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.