ArticleBMC genomics2016
Leveraging genetically simple traits to identify small-effect variants for complex phenotypes.
Article in BMC genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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25 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- Meta-analysis of sequence-based association studies across three cattle breeds reveals 25 QTL for fat and protein percentages in milk at nucleotide resolution.BMC genomics · 2017Pooled it
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- Cis-eQTLs in seven duck tissues identify novel candidate genes for growth and carcass traits.BMC genomics · 2024Article
- The eQTL colocalization and transcriptome-wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle.Journal of animal science and biotechnology · 2023Article
- Using QTL to Identify Genes and Pathways Underlying the Regulation and Production of Milk Components in Cattle.Animals : an open access journal from MDPI · 2023Review
- Genetic variation in histone modifications and gene expression identifies regulatory variants in the mammary gland of cattle.BMC genomics · 2022Article
- Sequence-based genome-wide association study of individual milk mid-infrared wavenumbers in mixed-breed dairy cattle.Genetics, selection, evolution : GSE · 2021Article
- A 12 kb multi-allelic copy number variation encompassing a GC gene enhancer is associated with mastitis resistance in dairy cattle.PLoS genetics · 2021Article
- Sequence-based GWAS and post-GWAS analyses reveal a key role of SLC37A1, ANKH, and regulatory regions on bovine milk mineral content.Scientific reports · 2021Article
- Response to Oxidative Burst-Induced Hypoxia Is Associated With Macrophage Inflammatory Profiles as Revealed by Cellular Genome-Wide Association.Frontiers in immunology · 2021Article
- Multiple association analysis of loci and candidate genes that regulate body size at three growth stages in Simmental beef cattle.BMC genetics · 2020Article
- Transcriptomic Profiles of Monocyte-Derived Macrophages in Response to Escherichia coli is Associated with the Host Genetics.Scientific reports · 2020Article
- The evolving role of Fourier-transform mid-infrared spectroscopy in genetic improvement of dairy cattle.Journal of animal science and biotechnology · 2020Review
- Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Multi-trait meta-analyses reveal 25 quantitative trait loci for economically important traits in Brown Swiss cattle.BMC genomics · 2019Article
- Sequence-based GWAS, network and pathway analyses reveal genes co-associated with milk cheese-making properties and milk composition in Montbéliarde cows.Genetics, selection, evolution : GSE · 2019Article
- Overlap between eQTL and QTL associated with production traits and fertility in dairy cattle.BMC genomics · 2019Article
- Harnessing genomic information for livestock improvement.Nature reviews. Genetics · 2019Review
- WidespreadRNA (New York, N.Y.) · 2019Article
- Multiple QTL underlie milk phenotypes at the CSF2RB locus.Genetics, selection, evolution : GSE · 2019Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPolymorphisms underlying complex traits often explain a small part (less than 1 %) of the phenotypic variance (σ
resultsQuantitative trait loci (QTL) were identified using 11,527 Holstein cattle with milk production records and up to 444 cows with milk composition traits. There were eight regions that contained QTL for both milk production and a composition trait, including four novel regions. One region on BTAU1 affected both milk yield and phosphorous concentration in milk. The QTL interval included the gene SLC37A1, a phosphorous antiporter. The most significant imputed sequence variants in this region explained 0.001 σ
conclusionsMilk production traits in dairy cows are typical complex traits where polymorphisms explain only a small portion of the phenotypic variance. However, here we show that these mutations can have larger effects on secondary traits, such as concentrations of minerals, proteins and sugars in the milk, and expression levels of genes in mammary tissue. These larger effects were used to successfully map variants for milk production traits. Genetically simple traits also provide a direct biological link between possible causal mutations and the effect of these mutations on milk production.
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