ArticlePreventing chronic disease2016
Multimorbidity and Functional Limitations Among Adults 65 or Older, NHANES 2005-2012.
Article in Preventing chronic disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
131 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- A Systematic Review of Outcomes Related to Nurse Practitioner-Delivered Primary Care for Multiple Chronic Conditions.Medical care research and review : MCRR · 2023Pooled it
- International depiction of the cost of functional independence limitations among older adults living in the community: a systematic review and cost-of-impairment study.BMC geriatrics · 2022Pooled it
- Measuring the Quality of Care for Older Adults With Multimorbidity: Results of the MULTIqual Project.The Gerontologist · 2022Pooled it
- Prediction models for functional status in community dwelling older adults: a systematic review.BMC geriatrics · 2022Pooled it
- Pooled it
- The patient at the centre: evidence from 17 European integrated care programmes for persons with complex needs.BMC health services research · 2020Pooled it
- Systematic Review of Technology-Based Interventions Targeting Chronically Ill Adults and Their Caregivers.Western journal of nursing research · 2020Pooled it
- Facilitators and Barriers to Adherence and Engagement in a Lifestyle Intervention for High-Risk Older Adults: A Multi-Trial Analysis.Nutrients · 2026Trial
- Small-Scale Randomized Controlled Trial to Explore the Impact of β-Hydroxy-β-Methylbutyrate Plus Vitamin DNutrients · 2022Trial
- Does the Mode of PROM Administration Affect the Responses of Hospitalized Patients?Archives of physical medicine and rehabilitation · 2022Trial
- Patterns of Home Environmental Modification Use and Functional Health: The Women's Health Initiative.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Trial
- The Effect of Active Plus, a Computer-Tailored Physical Activity Intervention, on the Physical Activity of Older Adults with Chronic Illness(es)-A Cluster Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Predictive validity of Alcohol Use Disorder Identification Test - Consumption (AUDIT-C) for register-based alcohol-attributable events among general-population men and women of different ages.Addiction (Abingdon, England) · 2026Article
- Asthma and Multimorbidity Amongst Ethnic Minority Groups in High Income Countries.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Review
- The Role of Subjective Vitality Among Older Adults from a Self-Determination Theory Perspective: A Scoping Review.Geriatrics (Basel, Switzerland) · 2026Review
- Performance-Based Usability of Medication Adherence Technologies Among Older Adults With Diverse Capabilities: Quantitative Study.JMIR aging · 2026Article
- Use of Claims Data to Screen for Functional Limitations Among Medicare Beneficiaries.JAMA health forum · 2026Article
- Article
- Design and test-retest reliability of a new test to assess motor competence in healthy older adults.GeroScience · 2026Article
- Multimorbidity Patterns and Obesity Among Americans Turning Forty.American journal of health promotion : AJHP · 2026Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
introductionThe development of functional limitations among adults aged 65 or older has profound effects on individual and population resources. Improved understanding of the relationship between functional limitations and co-occurring chronic diseases (multimorbidity) is an emerging area of interest. The objective of this study was to investigate the association between multimorbidity and functional limitations among community-dwelling adults 65 or older in the United States and explore factors that modify this association.
methodsWe conducted a cross-sectional analysis of adults aged 65 or older using data from the National Health and Nutrition Examination Survey (NHANES) from 2005 through 2012. We used negative binomial regression to estimate the association between multimorbidity (≥2 concurrent diseases) and functional limitations and to determine whether the association differed by sex or age.
resultsThe prevalence of multimorbidity in this population was 67% (95% confidence interval [CI], 65%-68%). Each additional chronic condition was associated with an increase in the number of functional limitations, and the association was stronger among those aged 75 or older than among those aged 65 to 74. For those aged 65 to 74, each additional chronic condition was associated with 1.35 (95% CI, 1.27-1.43) times the number of functional limitations for men and 1.62 times (95% CI, 1.31-2.02) the number of functional limitations for women. For those 75 or older, the associations increased to 1.71 (95% CI, 1.35-2.16) for men and 2.06 (95% CI, 1.51-2.81) for women for each additional chronic condition.
conclusionMultimorbidity was associated with increases in functional limitations, and the associations were stronger among women than among men and among adults aged 75 or older than among those aged 65 to 74. These findings underscore the importance of addressing age and sex differences when formulating prevention strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.