Evidence map›Paper›PMID 27809237›Full record

ReviewMolecules (Basel, Switzerland)2016

Discovery of Bioactive Compounds by the UIC-ICBG Drug Discovery Program in the 18 Years Since 1998.

Hong-Jie Zhang, Wan-Fei Li, Harry H S Fong, Djaja Doel Soejarto

Abstract readHistorical ArticleReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Plant-derived lignans as potential antiviral agents: a systematic review.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022
    Review
  3. Bioactive small-molecule constituents of Lao plants.Journal of medicinal plant research · 2021
    Article
  4. Review
  5. Antimalarial Activity of Plant Metabolites.International journal of molecular sciences · 2018
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hong-Jie ZhangSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. zhanghj@hkbu.edu.hk.
Wan-Fei LiSchool of Chinese Medicine, Hong Kong Baptist University, Hong Kong SAR, China. wanfeier@live.cn.
Harry H S FongDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. hfong@uic.edu.
Djaja Doel SoejartoDepartment of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. dds@uic.edu.

Funding

INVENTORY AND CONSERVATION OF PLANTS OF CUC PHUONG NATIONAL PARKU01TW001015 · FIC · UNIVERSITY OF ILLINOIS AT CHICAGO · PI SOEJARTO, DJAJA D · 1998 to 2010
$7.8M
FIC NIH HHS U01 TW001015
6 · The paper itself

Abstract

The International Cooperative Biodiversity Groups (ICBG) Program based at the University of Illinois at Chicago (UIC) is a program aimed to address the interdependent issues of inventory and conservation of biodiversity, drug discovery and sustained economic growth in both developing and developed countries. It is an interdisciplinary program involving the extensive synergies and collaborative efforts of botanists, chemists and biologists in the countries of Vietnam, Laos and the USA. The UIC-ICBG drug discovery efforts over the past 18 years have resulted in the collection of a cumulative total of more than 5500 plant samples (representing more than 2000 species), that were evaluated for their potential biological effects against cancer, HIV, bird flu, tuberculosis and malaria. The bioassay-guided fractionation and separation of the bioactive plant leads resulted in the isolation of approximately 300 compounds of varying degrees of structural complexity and/or biological activity. The present paper summarizes the significant drug discovery achievements made by the UIC-ICBG team of multidisciplinary collaborators in the project over the period of 1998-2012 and the projects carried on in the subsequent years by involving the researchers in Hong Kong.

Indexed as

AnimalsDrug DiscoveryHistory, 20th CenturyHistory, 21st CenturyHumansPhytotherapyPlant ExtractsPlant Extractsbioactive compoundscancerdrug discoveryHIVmalariatuberculosisUIC-ICBG

Identifiers

PMID27809237
PMCPMC6273581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.