ArticleScientific reports2016
Physical interactions between DNA and sepiolite nanofibers, and potential application for DNA transfer into mammalian cells.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Competition Between Protein and DNA for Binding to Natural Sepiolite Nanofibers.International journal of nanomedicine · 2025Article
- Intermittent lysis on a single paper-based device to extract exosomal nucleic acid biomarkers from biological samples for downstream analysis.Mikrochimica acta · 2024Article
- Cellular Alterations Due to Direct and Indirect Interaction of Nanomaterials with Nucleic Acids.International journal of molecular sciences · 2024Review
- Nanoclays for wound management applications.Drug delivery and translational research · 2023Review
- Halloysite Nanotubes and Sepiolite for Health Applications.International journal of molecular sciences · 2023Review
- Article
- Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk-shell and sepiolite nanomaterials.Beilstein journal of nanotechnology · 2023Article
- Fabrication and Analysis of Sepiolite/Glass Microcapsules/Liquid Crystal Polymer Composites.Molecules (Basel, Switzerland) · 2021Article
- Sepiolite-Hydrogels: Synthesis by Ultrasound Irradiation and Their Use for the Preparation of Functional Clay-Based Nanoarchitectured Materials.Frontiers in chemistry · 2021Article
- Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study.Molecules (Basel, Switzerland) · 2020Article
- The Use of Some Clay Minerals as Natural Resources for Drug Carrier Applications.Journal of functional biomaterials · 2018Review
- Cellular uptake pathways of sepiolite nanofibers and DNA transfection improvement.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanofibers of sepiolite, a natural silicate belonging to the clay minerals family, might constitute a potential promising nanocarrier for the non-viral transfer of bio-molecules. We show here that sepiolite nanofibers efficiently bind different types of DNA molecules through electrostatic interactions, hydrogen bonding, cation bridges, and van der Waals forces. Moreover, Fourier-transform infrared spectroscopy identified the external silanol groups as the main sites of interaction with the DNA. Furthermore, as a proof of concept, we show that sepiolite is able to stably transfer plasmid DNA into mammalian cells and that the efficiency can be optimized. Indeed, sonication of sepiolite 100-fold stimulated DNA transfection efficiency. These results open the way to the use of sepiolite-based biohybrids as a novel class of nanoplatform for gene transfer with potential clinical applications.
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Registered trials
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