ReviewNature reviews. Neurology2016
Unruptured intracranial aneurysms: development, rupture and preventive management.
Review in Nature reviews. Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT06405971 (Metformin in Patients With Unruptured Vertebrobasilar Dissecting Aneurysms), which is not on this map. Cited by 305 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Metformin in Patients With Unruptured Vertebrobasilar Dissecting Aneurysms: a Prospective, Randomized Study (METTLE)
Who cites it
305 citing papers in PubMed, 9 syntheses or guidelines pooled it, 596 citations in OpenAlex.
- Outcomes following intraoperative rupture of cerebral aneurysms during microsurgical clipping: a systematic review and meta-analysis.Neurosurgical review · 2026Pooled it
- Shifting the paradigm in intracranial aneurysm detection with deep learning: A diagnostic accuracy meta-analysis and meta-regression.Neurosurgical review · 2026Pooled it
- Management strategies and outcomes of basilar trunk aneurysms: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2026Pooled it
- Surgical treatment of giant intracranial aneurysms: A systematic review and single arm Meta-Analysis.Neurosurgical review · 2025Pooled it
- Association between systemic immune-inflammation index, systemic inflammation response index, and adverse outcomes in aneurysmal subarachnoid hemorrhage: a meta-analysis.Frontiers in neurology · 2025Pooled it
- Prediction of cerebral aneurysm rupture risk by machine learning algorithms: a systematic review and meta-analysis of 18,670 participants.Neurosurgical review · 2024Pooled it
- Predictive value of radiomics for intracranial aneurysm rupture: a systematic review and meta-analysis.Frontiers in neuroscience · 2024Pooled it
- The Role of NF-κB in Intracranial Aneurysm Pathogenesis: A Systematic Review.International journal of molecular sciences · 2023Pooled it
- Imaging of intracranial aneurysms in animals: a systematic review of modalities.Neurosurgical review · 2023Pooled it
- HSF-Net: a hybrid-scale fusion network for intracranial aneurysm segmentation in CTA images.Medical & biological engineering & computing · 2026Article
- Graph and Geometric Deep Learning for Intracranial Aneurysm Geometry and Hemodynamics: A Systematic Review with Implications for Neurovascular Implant Design and Evaluation.Life (Basel, Switzerland) · 2026Review
- Association Between the Systemic Immune-Inflammation Index and Aneurysmal Wall Enhancement on High-Resolution Magnetic Resonance Vessel Wall Imaging in Unruptured Intracranial Aneurysms.Journal of magnetic resonance imaging : JMRI · 2026Article
- Middle Cerebral Artery Bifurcation Geometry and Aneurysm Formation: A Propensity Score-Matched 3D Rotational Morphometry Study.Diagnostics (Basel, Switzerland) · 2026Article
- Systemic Hypertension and Predictors of Recanalization After Endovascular Coil Embolization of Intracranial Aneurysms: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- HMGB1 promotes intracranial aneurysm progression by regulating vascular smooth muscle cell phenotypic switching and ferroptosis.Journal of molecular histology · 2026Article
- MicroRNAs in Aneurysmal Subarachnoid Hemorrhage: A Stage-Specific Model Linking Rupture, Vasospasm, and Outcome.Biomedicines · 2026Review
- Estimating Rupture Risk of Intracranial Aneurysms: What We Know, What We Do Not Know, and What We Need.Stroke · 2026Review
- Morphological characteristics of brain aneurysms among age groups.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Aneurysm Wall Enhancement in Patients With Unruptured Intracranial Aneurysm Using Aspirin or Statins: A Cross-Sectional Analysis of Three Prospective Cohorts.AJNR. American journal of neuroradiology · 2026Article
- Impact of Metabolic Syndrome Components on Early Outcomes after Aneurysmal Subarachnoid Hemorrhage.Neurologia medico-chirurgica · 2026Article
245 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saccular unruptured intracranial aneurysms (UIAs) have a prevalence of 3% in the adult population, and are being increasingly detected because of improved quality and higher frequency of cranial imaging. Large amounts of data, providing varying levels of evidence, have been published on aneurysm development, progression and rupture, but less information is available on the risks and efficacy of preventive treatment. When deciding how to best manage UIAs, clinicians must consider the age and life expectancy of the patient, the estimated risk of rupture, the risk of complications attributed to preventive treatment, and the level of anxiety caused by the awareness of having an aneurysm. This Review highlights the latest human data on the formation, progression and rupture of intracranial aneurysms, as well as risks associated with preventive treatment. Considering these we discuss the implication for clinical management. Furthermore, we highlight pivotal questions arising from current data on intracranial aneurysms and the implications the data have for future experimental or clinical research. We also discuss data on novel radiological surrogates for rupture for those aneurysms that do not require preventive occlusion. Finally, we provide guidance for clinicians who are confronted with patients with incidentally detected UIAs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.