Evidence map›Paper›PMID 27808250›Full record

ArticleScientific reports2016

mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling.

Roberto Bravo-Sagua, Camila López-Crisosto, Valentina Parra, Marcelo Rodriguez-Peña, Beverly A Rothermel, Andrew F G Quest, Sergio Lavandero

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Review
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  5. Review
  6. Review
  7. DPAGT1-Perspective as an Anticancer Drug Target.Molecules (Basel, Switzerland) · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Dolutegravir induces endoplasmic reticulum stress at the blood-brain barrier.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  12. Article
  13. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Roberto Bravo-SaguaAdvanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences &Faculty of Medicine, University of Chile, Santiago, 8380492, Chile.
Camila López-CrisostoAdvanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences &Faculty of Medicine, University of Chile, Santiago, 8380492, Chile.
Valentina ParraAdvanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences &Faculty of Medicine, University of Chile, Santiago, 8380492, Chile.
Marcelo Rodriguez-PeñaAdvanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences &Faculty of Medicine, University of Chile, Santiago, 8380492, Chile.
Beverly A RothermelCardiology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, 75235, USA.
Andrew F G QuestAdvanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences &Faculty of Medicine, University of Chile, Santiago, 8380492, Chile.
Sergio LavanderoAdvanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical and Pharmaceutical Sciences &Faculty of Medicine, University of Chile, Santiago, 8380492, Chile.
University of Chile · CLAdvanced Center for Chronic Diseases · CLThe University of Texas Southwestern Medical Center · US

Funding

Calcineurin's role in circadian regulation of cardiac function and remodelingR01HL097768 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI ROTHERMEL, BEVERLY A · 2009 to 2012
$1.6M
MECHANISM OF ELASTASE INHIBITION BY RECOMBINANT SERPINSF32HL009051 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PLOTNICK, MICHAEL I · 1994 to 1995
–
NHLBI NIH HHS F32 HL009051NHLBI NIH HHS R01 HL097768
6 · The paper itself

Abstract

Efficient mitochondrial Ca

Indexed as

CalciumCell Line, TumorEndoplasmic ReticulumHeLa CellsHumansMembrane Potential, MitochondrialMitochondriaSirolimusTunicamycinCalciumSirolimusTunicamycin

Identifiers

PMID27808250
PMCPMC5093439
OpenAlexW2548251447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.