ArticleScientific reports2016
Cascading and Parallelising Curvilinear Inertial Focusing Systems for High Volume, Wide Size Distribution, Separation and Concentration of Particles.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Enhancing particle focusing: a comparative experimental study of modified square wave and square wave microchannels in lift and Dean vortex regimes.Scientific reports · 2024Article
- Development of a microfluidic cell transfection device into gene-edited CAR T cell manufacturing workflow.Lab on a chip · 2023Article
- Multicurvature viscous streaming: Flow topology and particle manipulation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Scaling microfluidic throughput with flow-balanced manifolds to simply control devices with multiple inlets and outlets.Biomicrofluidics · 2022Article
- Multi-dimensional-double-spiral (MDDS) inertial microfluidic platform for sperm isolation directly from the raw semen sample.Scientific reports · 2022Article
- 3D-Stacked Multistage Inertial Microfluidic Chip for High-Throughput Enrichment of Circulating Tumor Cells.Cyborg and bionic systems (Washington, D.C.) · 2022Article
- Progress of Microfluidic Continuous Separation Techniques for Micro-/Nanoscale Bioparticles.Biosensors · 2021Review
- Purifying stem cell-derived red blood cells: a high-throughput label-free downstream processing strategy based on microfluidic spiral inertial separation and membrane filtration.Biotechnology and bioengineering · 2020Article
- 3D Printing of Inertial Microfluidic Devices.Scientific reports · 2020Article
- Label-free microfluidic sorting of microparticles.APL bioengineering · 2019Review
- Spiral microfluidic devices for cell separation and sorting in bioprocesses.Biomicrofluidics · 2019Review
- Microfluidic technology for plankton research.Current opinion in biotechnology · 2019Review
- Inertial-Based Filtration Method for Removal of Microcarriers from Mesenchymal Stem Cell Suspensions.Scientific reports · 2018Article
- Oscillatory inertial focusing in infinite microchannels.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Impact of poloxamer 188 (Pluronic F-68) additive on cell mechanical properties, quantification by real-time deformability cytometry.Biomicrofluidics · 2018Article
- High-throughput assessment of mechanical properties of stem cell derived red blood cells, toward cellular downstream processing.Scientific reports · 2017Article
- Microfluidic Cell Retention Device for Perfusion of Mammalian Suspension Culture.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Inertial focusing is a microfluidic based separation and concentration technology that has expanded rapidly in the last few years. Throughput is high compared to other microfluidic approaches although sample volumes have typically remained in the millilitre range. Here we present a strategy for achieving rapid high volume processing with stacked and cascaded inertial focusing systems, allowing for separation and concentration of particles with a large size range, demonstrated here from 30 μm-300 μm. The system is based on curved channels, in a novel toroidal configuration and a stack of 20 devices has been shown to operate at 1 L/min. Recirculation allows for efficient removal of large particles whereas a cascading strategy enables sequential removal of particles down to a final stage where the target particle size can be concentrated. The demonstration of curved stacked channels operating in a cascaded manner allows for high throughput applications, potentially replacing filtration in applications such as environmental monitoring, industrial cleaning processes, biomedical and bioprocessing and many more.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.