ArticleScientific reports2016
Directional and reoccurring sequence change in zoonotic RNA virus genomes visualized by time-series word count.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Oligonucleotide usage in coronavirus genomes mimics that in exon regions in host genomes.Virology journal · 2023Article
- On the Evolutionary Trajectory of SARS-CoV-2: Host Immunity as a Driver of Adaptation in RNA Viruses.Viruses · 2022Review
- Unsupervised explainable AI for molecular evolutionary study of forty thousand SARS-CoV-2 genomes.BMC microbiology · 2022Article
- Genome sequence diversity of SARS-CoV-2 obtained from clinical samples in Uzbekistan.PloS one · 2022Article
- AI-based search for convergently expanding, advantageous mutations in SARS-CoV-2 by focusing on oligonucleotide frequencies.PloS one · 2022Article
- Mutational spectrum of SARS-CoV-2 during the global pandemic.Experimental & molecular medicine · 2021Article
- The Evolution of Severe Acute Respiratory Syndrome Coronavirus-2 during Pandemic and Adaptation to the Host.Journal of molecular evolution · 2021Article
- Human cell-dependent, directional, time-dependent changes in the mono- and oligonucleotide compositions of SARS-CoV-2 genomes.BMC microbiology · 2021Article
- Article
- Time-series oligonucleotide count to assign antiviral siRNAs with long utility fit in the big data era.Gene therapy · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ebolavirus, MERS coronavirus and influenza virus are zoonotic RNA viruses, which mutate very rapidly. Viral growth depends on many host factors, but human cells may not provide the ideal growth conditions for viruses invading from nonhuman hosts. The present time-series analyses of short and long oligonucleotide compositions in these genomes showed directional changes in their composition after invasion from a nonhuman host, which are thought to recur after future invasions. In the recent West Africa Ebola outbreak, directional time-series changes in a wide range of oligonucleotides were observed in common for three geographic areas, and the directional changes were observed also for the recent MERS coronavirus epidemics starting in the Middle East. In addition, common directional changes in human influenza A viruses were observed for three subtypes, whose epidemics started independently. Long oligonucleotides that showed an evident directional change observed in common for the three subtypes corresponded to some of influenza A siRNAs, whose activities have been experimentally proven. Predicting directional and reoccurring changes in oligonucleotide composition should become important for designing diagnostic RT-PCR primers and therapeutic oligonucleotides with long effectiveness.
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