Evidence map›Paper›PMID 27807925›Full record

Trial reportObesity (Silver Spring, Md.)2016

Meal replacements followed by topiramate for the treatment of adolescent severe obesity: A pilot randomized controlled trial.

Claudia K Fox, Alexander M Kaizer, Kyle D Rudser, Brandon M Nathan, Amy C Gross, Muna Sunni, M Jennifer Abuzzahab, Betsy L Schwartz, Seema Kumar, Anna Petryk and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Treatment of adolescent obesity.Nature reviews. Endocrinology · 2018
    Pooled it
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  8. A Systemic Review of Pharmacological Management of Pediatric Obesity.Journal of pharmacy & bioallied sciences · 2025
    Review
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Claudia K FoxDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Alexander M KaizerDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.
Kyle D RudserDivision of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.
Brandon M NathanDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Amy C GrossDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Muna SunniDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
M Jennifer AbuzzahabChildren's Hospitals and Clinics of Minnesota, Minneapolis, Minnesota, USA.
Betsy L SchwartzInternational Diabetes Center at Park Nicollet, St. Louis Park, Minnesota, USA.
Seema KumarMayo Clinic, Rochester, Minnesota, USA.
Anna PetrykDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Charles J BillingtonVeterans Affairs Health Care System, Minneapolis, Minnesota, USA.
Justin R RyderDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.
Aaron S KellyDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR000114 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R · 2012 to 2015
$35.0M
Obesity and Energy Metabolism CoreP30DK050456 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CROW, SCOTT J · 1995 to 2015
$17.0M
Longitudinal assessment of novel biomarkers for predicting cardiovascular disease in youthF32HL127851 · NHLBI · UNIVERSITY OF MINNESOTA · PI RYDER, JUSTIN R. · 2015 to 2016
$61k
NCATS NIH HHS UL1 TR000114NHLBI NIH HHS F32 HL127851NIDDK NIH HHS P30 DK050456
6 · The paper itself

Abstract

objectiveTo assess the safety and efficacy of short-term meal replacement therapy followed by topiramate for body mass index (BMI) reduction in adolescents with severe obesity.

methodsAdolescents (ages 12-18 years) with severe obesity (BMI ≥1.2 times the 95th percentile or BMI ≥35 kg/m

resultsThirty adolescents (mean age 15.2 ± 1.7 years, mean BMI 40.3 ± 4.6 kg/m

conclusionsIn this pilot study, 4 weeks of meal replacement therapy followed by 24 weeks of low-dose topiramate compared with meal replacement therapy alone did not result in significant BMI reduction for adolescents with severe obesity.

Indexed as

MealsAdolescentAnti-Obesity AgentsBody ConstitutionBody Mass IndexDouble-Blind MethodFemaleFructoseHumansLipoproteins, VLDLMalePediatric ObesityPilot ProjectsTopiramateTreatment OutcomeAnti-Obesity AgentsFructoseLipoproteins, VLDLTopiramate

Identifiers

PMID27807925
PMCPMC5125846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.