ArticleHuman brain mapping2017
Local gyrification index in patients with major depressive disorder and its association with tryptophan hydroxylase-2 (TPH2) polymorphism.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Anomalous brain gyrification patterns in major psychiatric disorders: a systematic review and transdiagnostic integration.Translational psychiatry · 2021Pooled it
- Neuroimaging genomic studies in major depressive disorder: A systematic review.CNS neuroscience & therapeutics · 2018Pooled it
- Predicting trail-making test performance using 7-Tesla structural cerebral MRI.Translational psychiatry · 2026Article
- Reduced cortical gyrification in type 1 diabetes is associated with white matter integrity loss and cognitive decline.Metabolic brain disease · 2026Article
- Association between Cortical Gyrification and Major Depression: Clinical Correlates.Psychopathology · 2026Article
- Structural alterations as a predictor of depression - a 7-Tesla MRI-based multidimensional approach.Molecular psychiatry · 2025Article
- Sex Differences in Cortical Structural Alterations in Major Depressive Disorder With Suicidal Ideation.Depression and anxiety · 2025Article
- Cholinergic basal forebrain atrophy in Parkinson's disease with freezing of gait.Annals of clinical and translational neurology · 2023Article
- Gyrification patterns in first-episode, drug-naïve major depression: Associations with plasma levels of brain-derived neurotrophic factor and psychiatric symptoms.Frontiers in psychiatry · 2022Article
- Brain morphometric abnormalities and their associations with affective symptoms in males with methamphetamine use disorder during abstinence.Frontiers in psychiatry · 2022Article
- Longitudinal Changes in Brain Gyrification in Schizophrenia Spectrum Disorders.Frontiers in aging neuroscience · 2021Article
- Temporally and sex-specific effects of maternal perinatal stress on offspring cortical gyrification and mood in young adulthood.Human brain mapping · 2020Article
- Roles of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphisms in First-Episode, Drug-Naive Adult Patients With Depression.Frontiers in psychiatry · 2020Article
- Altered Local Gyrification Index and Corresponding Functional Connectivity in Medication Free Major Depressive Disorder.Frontiers in psychiatry · 2020Article
- Age-related atrophy of cortical thickness and genetic effect of ANK3 gene in first episode MDD patients.NeuroImage. Clinical · 2020Article
- Molecular Biomarkers Predictive of Sertraline Treatment Response in Young Children With Autism Spectrum Disorder.Frontiers in genetics · 2020Article
- Network-based decoupling of local gyrification in obsessive-compulsive disorder.Human brain mapping · 2018Article
- TPH-2 Gene Polymorphism in Major Depressive Disorder Patients With Early-Wakening Symptom.Frontiers in neuroscience · 2018Article
- Lifespan Gyrification Trajectories of Human Brain in Healthy Individuals and Patients with Major Psychiatric Disorders.Scientific reports · 2017Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tryptophan hydroxylase-2 (TPH2) gene is considered a promising genetic candidate regarding its association with a predisposition to major depressive disorder (MDD). Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. They aimed to investigate the alterations in the cortical gyrification of the prefrontal cortex and anterior cingulate cortex and their association with the TPH2 rs4570625 polymorphism in patients with MDD. One hundred and thirteen patients with MDD and eighty-six healthy controls underwent T1-weighted structural magnetic resonance imaging and genotyping for TPH2 rs4570625. The local gyrification index of 22 cortical regions in the prefrontal cortex and anterior cingulate cortex was analyzed using the FreeSurfer. The patients with MDD showed significant hypergyria in the right rostral anterior cingulate cortex (P = 0.001), medial orbitofrontal cortex (P = 0.003), and frontal pole (P = 0.001). There was a significant genotype-by-diagnosis interaction for the local gyrification index in the right rostral anterior cingulate cortex (P = 0.003). Their study revealed significant hypergyria of the anterior cingulate cortex and prefrontal cortex and an interactive effect between the diagnosis of MDD and the genotype in the anterior cingulate cortex. This might be associated with the dysfunction of neural circuits mediating emotion processing, which could contribute to pathophysiology of MDD. Hum Brain Mapp 38:1299-1310, 2017. © 2016 Wiley Periodicals, Inc.
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