Evidence map›Paper›PMID 27807801›Full record

ArticleTranslational stroke research2017

Role of Glibenclamide in Brain Injury After Intracerebral Hemorrhage.

Bing Jiang, Lin Li, Qianwei Chen, Yihao Tao, Liming Yang, Bo Zhang, John H Zhang, Hua Feng, Zhi Chen, Jun Tang and 1 more

Retracted Registry-linked trialAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Translational stroke research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. It is linked to trial NCT03741530 (Glibenclamide Advantage in Treating Edema After Intracerebral Hemorrhage), which is not on this map. Cited by 70 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 3 pooled it
9.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03741530 nacompletednot on this mapstarted 2018, after this paper: background citation

Glibenclamide Advantage in Treating Edema After Intracerebral Hemorrhage (GATE-ICH): a Multi-center Randomized, Controlled, Assessor-blinded Trial

TypeinterventionalSponsorXijing HospitalRan2018 to 2020Enrolled220ConditionsIntracerebral HemorrhageArmsGlibenclamide Tablets, Standard management for ICH
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 112 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. New targets in spontaneous intracerebral hemorrhage.Current opinion in neurology · 2025
    Review
  11. The role of MMPs in intracerebral hemorrhage.Frontiers in cell and developmental biology · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Bing JiangDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China.
Lin LiDepartment of Neurosurgery, Nanchong Central Hospital, Sichuan, 637000, China.
Qianwei ChenDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China.
Yihao TaoDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China.
Liming YangDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China.
Bo ZhangDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China.
John H ZhangDepartment of Neurosurgery, School of Medicine, Loma Linda University, Loma Linda, CA, USA.
Hua FengDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China.
Zhi ChenDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China.
Jun TangDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China. tangjun@tmmu.edu.cn.
Gang ZhuDepartment of Neurosurgery, Southwest Hospital, Third Military Medical University, No. 30, Gaotanyan Street, Chongqing, 400038, People's Republic of China. gangzhu6666@sina.com.
Southwest Hospital · CNArmy Medical University · CNLoma Linda University · USNanchong Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain edema following intracerebral hemorrhage (ICH) causes severe secondary brain injury, and no efficient pharmacological preventions are available. The present study was designed to demonstrate the neuroprotective effects of glibenclamide on brain edema and key factors of the blood-brain barrier (BBB). The study was divided into two parts. First, we utilized an autoblood-induced rat model to investigate the expression of sulfonylurea receptor 1 (Sur1). Second, rats were randomized into sham, vehicle, and glibenclamide groups. Neurological scores, brain water content, Evans blue extravasation, Morris water maze test, western blots, and immunofluorescence were used to study the effects of glibenclamide. The expression of the Sur1-Trpm4 channel but not the Sur1-KATP channel was increased in the perihematomal tissue following ICH. Glibenclamide administration significantly decreased the brain water content, restored the BBB, and reduced the expression of MMPs. In addition, glibenclamide improved long-term cognitive deficits following ICH. Glibenclamide protected BBB integrity and improved neurological outcomes after ICH by inhibiting the Sur1-Trpm4 channel, which reduces the expression of MMPs and thereby increases BBB tight-junction protein levels. Glibenclamide may have potential to protect the BBB after ICH.

Indexed as

AnimalsBlood-Brain BarrierBlood GlucoseBrain EdemaCerebral HemorrhageEndotheliumGlyburideKcnj11 ChannelMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Maze LearningOccludinPotassium Channels, Inwardly RectifyingRatsRats, Sprague-DawleyAbcc8 protein, ratBlood GlucoseGlyburideKcnj11 ChannelMatrix Metalloproteinase 2Matrix Metalloproteinase 9OccludinOcln protein, ratPotassium Channels, Inwardly RectifyingSulfonylurea ReceptorsTjp1 protein, ratTRPM4 protein, ratTRPM Cation ChannelsZonula Occludens-1 ProteinBBBGlibenclamideIntracerebral hemorrhageMMPsSur1

Identifiers

PMID27807801
OpenAlexW2546854374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.