Evidence map›Paper›PMID 27807666›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2017

Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study.

Emer M Guinan, Suzanne L Doyle, Linda O'Neill, Margaret R Dunne, Emma K Foley, Jacintha O'Sullivan, John V Reynolds, Juliette Hussey

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
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  6. Head and neck cancer rehabilitation: the CaRe feasibility study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
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  20. Patient experiences of a physiotherapy-led multidisciplinary rehabilitative intervention after successful treatment for oesophago-gastric cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Emer M GuinanSchool of Medicine, Trinity College Dublin, Dublin, Ireland. emguinan@tcd.ie.
Suzanne L DoyleTrinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, Dublin, Ireland.
Linda O'NeillDiscipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland.
Margaret R DunneTrinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, Dublin, Ireland.
Emma K FoleyTrinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, Dublin, Ireland.
Jacintha O'SullivanTrinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, Dublin, Ireland.
John V ReynoldsTrinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin, Dublin, Ireland.
Juliette HusseyDiscipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland.
Trinity College Dublin · IESt. James's Hospital · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePhysical, nutritional and quality-of-life compromises are known sequelae of oesophageal cancer (OC) treatment. Inflammation and oxidative stress may be relevant to adverse consequences. Multimodal rehabilitation involving exercise and diet prescription may attenuate some of the negative consequences and optimise survivorship, and this was assessed in this feasibility study in OC patients at least 1 year post-oesophagectomy.

methodsThe 12-week programme included supervised and home-based exercise, dietetic counselling to ensure energy balance and multidisciplinary education. Baseline and post-intervention assessments examined aerobic fitness, physical activity and body composition. Serum interleukin (IL)-1β, tumour necrosis factor (TNF)-α, IL-6 and IL-8 were measured via multiplex arrays. Lactate secretion, lipid peroxidation (4-HNE) and oxidative stress (8-iso-PGF2α) were measured by enzyme-linked immunosorbent assay (ELISA).

resultsTwelve patients (mean (SD) age 64(1.29) years) participated. IL-8 reduced significantly from pre- to post-intervention (percentage change -11.25 % (95 % CI -20.98 to -1.51 %), p = 0.03), and there was a non-significant trend towards lower expression patterns of other inflammatory mediators. At baseline, inflammatory status correlated inversely with sedentary behaviour (IL-6 rho = -0.74, IL-8 rho = -0.59, TNF-α rho = -0.69; p < 0.05). While energy metabolism did not change, post-intervention lactate concentration correlated strongly and inversely with aerobic fitness (rho = -0.68, p = 0.02). Body composition was maintained throughout the intervention.

conclusionsResults suggest that multimodal rehabilitation following OC treatment reduced inflammatory status without compromising body composition. Findings will be further examined in a larger randomised controlled trial.

Indexed as

DietExerciseEsophageal NeoplasmsFeasibility StudiesFemaleHumansInflammationInterleukinsMaleMiddle AgedOxidative StressProspective StudiesQuality of LifeSurvivorsInterleukinsCancer survivorsDietEducationExerciseOesophageal cancerRehabilitation

Identifiers

PMID27807666
OpenAlexW2548315011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.